TY - JOUR
T1 - Staphylococcus aureus pore-forming toxins
T2 - The interface of pathogen and host complexity
AU - Seilie, E. Sachiko
AU - Bubeck Wardenburg, Juliane
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/12
Y1 - 2017/12
N2 - Staphylococcus aureus is a prominent human pathogen capable of infecting a variety of host species and tissue sites. This versatility stems from the pathogen's ability to secrete diverse host-damaging virulence factors. Among these factors, the S. aureus pore-forming toxins (PFTs) α-toxin and the bicomponent leukocidins, have garnered much attention for their ability to lyse cells at low concentrations and modulate disease severity. Although many of these toxins were discovered nearly a century ago, their host cell specificities have only been elucidated over the past five to six years, starting with the discovery of the eukaryotic receptor for α-toxin and rapidly followed by identification of the leukocidin receptors. The identification of these receptors has revealed the species- and cell type-specificity of toxin binding, and provided insight into non-lytic effects of PFT intoxication that contribute to disease pathogenesis.
AB - Staphylococcus aureus is a prominent human pathogen capable of infecting a variety of host species and tissue sites. This versatility stems from the pathogen's ability to secrete diverse host-damaging virulence factors. Among these factors, the S. aureus pore-forming toxins (PFTs) α-toxin and the bicomponent leukocidins, have garnered much attention for their ability to lyse cells at low concentrations and modulate disease severity. Although many of these toxins were discovered nearly a century ago, their host cell specificities have only been elucidated over the past five to six years, starting with the discovery of the eukaryotic receptor for α-toxin and rapidly followed by identification of the leukocidin receptors. The identification of these receptors has revealed the species- and cell type-specificity of toxin binding, and provided insight into non-lytic effects of PFT intoxication that contribute to disease pathogenesis.
KW - Alpha-toxin
KW - Hemolysin
KW - Leukocidin
KW - Pore-forming toxins
KW - S. aureus vaccines and therapeutics
KW - Staphylococcus aureus
UR - http://www.scopus.com/inward/record.url?scp=85018405739&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2017.04.003
DO - 10.1016/j.semcdb.2017.04.003
M3 - Review article
C2 - 28445785
AN - SCOPUS:85018405739
SN - 1084-9521
VL - 72
SP - 101
EP - 116
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -