Staging of mediastinal non-small cell lung cancer with FDG PET, CT, and fusion images: Preliminary prospective evaluation

Richard L. Wahl, Leslie E. Quint, Robert L. Greenough, Charles R. Meyer, Richard I. White, Mark B. Orringer

Research output: Contribution to journalArticlepeer-review

437 Scopus citations

Abstract

PURPOSE: To evaluate use of positron emission tomography (PET) with 2- [fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in detection of mediastinal lymph node metastases from non-small cell lung cancer. MATERIALS AND METHODS: A prospective trial to compare FDG PET and computed tomography (CT) of the thorax was performed in 23 patients with newly diagnosed or suspected non- small cell lung cancer. Blinded interpretations of CT alone, PET alone, CT and PET together, and fusion images were performed, and the results were compared with pathologic results. RESULTS: Nineteen of 23 patients had non- small cell lung cancer. Prevalence of mediastinal involvement was 41%. In staging disease in the mediastinum, CT alone was 64% sensitive, 44% specific, and 52% accurate, whereas PET alone and fusion images were 82% sensitive, 81% specific, and 81% accurate (P < .05). CONCLUSIONS: FDG PET was more accurate than CT in staging disease in the mediastinum in patients with lung cancer and appears to be the preferred imaging method in this clinical setting.

Original languageEnglish
Pages (from-to)371-377
Number of pages7
JournalRadiology
Volume191
Issue number2
DOIs
StatePublished - May 1994

Keywords

  • Computed tomography (CT), comparative studies
  • Emission CT (ECT)
  • Lymphatic system, neoplasms
  • Mediastinum, CT
  • Mediastinum, neoplasms

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