TY - JOUR
T1 - Stage iv rectal cancer and timing of surgical approach
AU - Panni, Roheena Z.
AU - D'Angelica, Michael
N1 - Publisher Copyright:
© 2023. Thieme. All rights reserved.
PY - 2024/6/14
Y1 - 2024/6/14
N2 - Liver metastases are seen in at least 60% of patients with colorectal cancer at some point during the course of their disease. The management of both primary and liver disease is uniquely challenging in rectal cancer due to competing treatments and complex sequence of treatments depending on the clinical presentation of disease. Recently, several novel concepts are shaping new treatment paradigms, including changes in timing, sequence, and duration of therapies combined with potential deescalation of treatment components. Overall, the treatment of this clinical scenario mandates multidisciplinary evaluation and personalization of care; however, there is still considerable debate regarding the timing of liver metastasectomy in the context of the overall treatment plan. Herein, we will discuss the current literature on management of rectal cancer with synchronous liver metastasis, current treatment approaches with respect to chemotherapy, and role of hepatic artery infusion therapy.
AB - Liver metastases are seen in at least 60% of patients with colorectal cancer at some point during the course of their disease. The management of both primary and liver disease is uniquely challenging in rectal cancer due to competing treatments and complex sequence of treatments depending on the clinical presentation of disease. Recently, several novel concepts are shaping new treatment paradigms, including changes in timing, sequence, and duration of therapies combined with potential deescalation of treatment components. Overall, the treatment of this clinical scenario mandates multidisciplinary evaluation and personalization of care; however, there is still considerable debate regarding the timing of liver metastasectomy in the context of the overall treatment plan. Herein, we will discuss the current literature on management of rectal cancer with synchronous liver metastasis, current treatment approaches with respect to chemotherapy, and role of hepatic artery infusion therapy.
KW - colorectal liver metastasis
KW - metastatic rectal cancer
KW - timing of surgery
UR - http://www.scopus.com/inward/record.url?scp=85168338017&partnerID=8YFLogxK
U2 - 10.1055/s-0043-1770719
DO - 10.1055/s-0043-1770719
M3 - Article
C2 - 38882938
AN - SCOPUS:85168338017
SN - 1531-0043
VL - 37
SP - 248
EP - 255
JO - Clinics in Colon and Rectal Surgery
JF - Clinics in Colon and Rectal Surgery
IS - 4
ER -