Stable neurological function in subjects treated with 2'3'dideoxyinosine

J. J. Sidtis, U. Dafni, Peter Slasor, C. Hall, R. W. Price, K. Kieburtz, T. Tucker, D. B. Clifford

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


AIDS Dementia Complex (ADC) is a frequent and devastating complication of HIV infection. There is evidence that zidovudine (ZDV) has an effect in alleviating the symptoms of ADC, and may have a role in its prevention. It is therefore important that new antiretroviral therapies be evaluated not only for the risk of neurologic side effects, but also for their relative efficacy to ZDV in the prevention of ADC. The present study reports the effects of 2'3'dideoxyinosine (DDI, didanosine, Videx) therapy on neuropsychological performance in the context of several large clinical trials targeting advanced systemic HIV-1 infection. Subjects treated with DDI had stable neurologic performance in quantitative tests over a 1 year period and were similar to zidovudine treated subjects.

Original languageEnglish
Pages (from-to)233-240
Number of pages8
JournalJournal of NeuroVirology
Issue number3
StatePublished - Jun 1997


  • AIDS dementia
  • Acquired immunodeficiency syndrome
  • DDI
  • Didanosine
  • HIV
  • Zidovudine


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