Stability of and inflammatory response to silicon coated with a fluoroalkyl self-assembled monolayer in the central nervous system

Anfeng Wang, Xuemei Liang, James P. McAllister, Jie Li, Kelley Brabant, Carolyn Black, Paul Finlayson, Ting Cao, Haiying Tang, Steven O. Salley, Gregory W. Auner, K. Y.Simon Ng

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A self-assembled monolayer (SAM) of fluoroalkyl silane (FAS) (CF 3(CF2)5(CH2)2SiCl 3) was deposited on the surface of silicon wafers, aiming to enhance its stability and to reduce the inflammatory response in the central nervous system. Following implantation of the FAS SAM coated silicon in rat brains, the FAS SAM coating failed to reduce the inflammatory response of silicon, because it could not prevent the corrosion of the underlying silicon. The corrosion was hindered for the initial 10 days by the FAS SAM coating, but there was nearly no difference when compared to the uncoated silicon when the implantation periods were extended to 28 and 90 days. The FAS SAM coating was completely removed within 28 and 90 days. Meanwhile, on all the extracted uncoated and FAS SAM coated silicon wafers, there were proteinaceous substances deposited on the surfaces, and the amount of the deposits increased with exposure time.

Original languageEnglish
Pages (from-to)363-372
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume81
Issue number2
DOIs
StatePublished - May 1 2007
Externally publishedYes

Keywords

  • Biostability
  • Fluoroalkyl silane
  • Inflammatory response
  • Self-assembled monolayer
  • Silicon

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    Wang, A., Liang, X., McAllister, J. P., Li, J., Brabant, K., Black, C., Finlayson, P., Cao, T., Tang, H., Salley, S. O., Auner, G. W., & Ng, K. Y. S. (2007). Stability of and inflammatory response to silicon coated with a fluoroalkyl self-assembled monolayer in the central nervous system. Journal of Biomedical Materials Research - Part A, 81(2), 363-372. https://doi.org/10.1002/jbm.a.31034