Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement

Kentaro Matsuoka; Satoshi Hayashi; Fumihiko Urano; Lihua J. Zhu; Hajime Okita; Haruhiko Sago; Atsuko Nakazawa

doi:10.1016/j.humpath.2011.10.017

Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement

Kentaro Matsuoka, Satoshi Hayashi, Fumihiko Urano, Lihua J. Zhu, Hajime Okita, Haruhiko Sago, Atsuko Nakazawa

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that thoracoamniotic shunting can cause histologic changes in the cyst epithelia. In 5 of 8 patients treated prenatally with thoracoamniotic shunting, squamous metaplasia in the cyst epithelia was seen; whereas squamous metaplasia was not found in 6 patients who were not treated with this procedure. Our results reveal that long-term exposure to the intrauterine environment could possibly lead to the change in the nature of cyst epithelium and consequent squamous metaplasia.

Original language	English
Pages (from-to)	1413-1417
Number of pages	5
Journal	Human Pathology
Volume	43
Issue number	9
DOIs	https://doi.org/10.1016/j.humpath.2011.10.017
State	Published - Sep 2012

Keywords

Congenital pulmonary airway malformation
Cyst epithelium
Squamous metaplasia
Thoracoamniotic shunting

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10.1016/j.humpath.2011.10.017

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title = "Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement",

abstract = "Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that thoracoamniotic shunting can cause histologic changes in the cyst epithelia. In 5 of 8 patients treated prenatally with thoracoamniotic shunting, squamous metaplasia in the cyst epithelia was seen; whereas squamous metaplasia was not found in 6 patients who were not treated with this procedure. Our results reveal that long-term exposure to the intrauterine environment could possibly lead to the change in the nature of cyst epithelium and consequent squamous metaplasia.",

keywords = "Congenital pulmonary airway malformation, Cyst epithelium, Squamous metaplasia, Thoracoamniotic shunting",

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AU - Matsuoka, Kentaro

AU - Hayashi, Satoshi

AU - Urano, Fumihiko

AU - Zhu, Lihua J.

AU - Okita, Hajime

AU - Sago, Haruhiko

AU - Nakazawa, Atsuko

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AB - Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that thoracoamniotic shunting can cause histologic changes in the cyst epithelia. In 5 of 8 patients treated prenatally with thoracoamniotic shunting, squamous metaplasia in the cyst epithelia was seen; whereas squamous metaplasia was not found in 6 patients who were not treated with this procedure. Our results reveal that long-term exposure to the intrauterine environment could possibly lead to the change in the nature of cyst epithelium and consequent squamous metaplasia.

KW - Congenital pulmonary airway malformation

KW - Cyst epithelium

KW - Squamous metaplasia

KW - Thoracoamniotic shunting

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Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement

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Keywords

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