TY - JOUR
T1 - Squamous cell cancer of the head and neck with distant metastasis at presentation
AU - Kuperman, David I.
AU - Auethavekiat, Vorachart
AU - Adkins, Douglas R.
AU - Nussenbaum, Brian
AU - Collins, Sharon
AU - Boonchalermvichian, Chaiyaporn
AU - Trinkaus, Kathryn
AU - Chen, Ling
AU - Morgensztern, Daniel
PY - 2011/5
Y1 - 2011/5
N2 - Background. Current literature reports widely different rates of distant metastasis at presentation for squamous cell carcinoma of the head and neck (SCCHN). We used the Surveillance Epidemiology and End Results (SEER) database to determine the rate of and risk factors for distant metastasis. Methods. We identified patients with SCCHN diagnosed between 1988 and 2003. The rate of distant metastasis was determined and then stratified by tumor site, size, and nodal status. To evaluate the contribution of each individual factor, both univariate and multivariate analyses were performed. Results. Among 73,247 patients identified, 2066 patients (2.82%, 95% confidence interval [CI] 2.70-2.94%) had distant metastasis. Independent risk factors for distant metastasis included primary site, nodal status, tumor size, age, and race. Conclusions. In SCCHN, there is a relationship between the risk of distant metastasis and tumor site, size, and nodal status. This information can be used to guide the evaluation and treatment of SCCHN.
AB - Background. Current literature reports widely different rates of distant metastasis at presentation for squamous cell carcinoma of the head and neck (SCCHN). We used the Surveillance Epidemiology and End Results (SEER) database to determine the rate of and risk factors for distant metastasis. Methods. We identified patients with SCCHN diagnosed between 1988 and 2003. The rate of distant metastasis was determined and then stratified by tumor site, size, and nodal status. To evaluate the contribution of each individual factor, both univariate and multivariate analyses were performed. Results. Among 73,247 patients identified, 2066 patients (2.82%, 95% confidence interval [CI] 2.70-2.94%) had distant metastasis. Independent risk factors for distant metastasis included primary site, nodal status, tumor size, age, and race. Conclusions. In SCCHN, there is a relationship between the risk of distant metastasis and tumor site, size, and nodal status. This information can be used to guide the evaluation and treatment of SCCHN.
KW - SEER
KW - epidemiology
KW - head and neck
KW - metastasis
KW - squamous cell cancer
UR - http://www.scopus.com/inward/record.url?scp=79954558424&partnerID=8YFLogxK
U2 - 10.1002/hed.21529
DO - 10.1002/hed.21529
M3 - Article
C2 - 20872838
AN - SCOPUS:79954558424
SN - 1043-3074
VL - 33
SP - 714
EP - 718
JO - Head and Neck
JF - Head and Neck
IS - 5
ER -