TY - JOUR
T1 - Spongiform degeneration of the gerbil cochlear nucleus
T2 - An ultrastructural and immunohistochemical evaluation
AU - Faddis, B. T.
AU - Mcginn, M. D.
N1 - Funding Information:
This work was supported by NIH/NIDCO grants DC000263-08 to Richard A. Chole and DC00057 to Michael D. McGinn, and by the Department of Otolaryngology in the School of Medicine at the University of California, Davis.
PY - 1997
Y1 - 1997
N2 - Observations from ultrastructural and immunohistochemical studies suggest that spongiform lesions in the gerbil cochlear nucleus are derived principally from dendrites. Almost one-fifth of the lesion profiles examined ultrastructurally exhibited synaptic contacts with axon terminals. In addition, approximately 80% of lesions are immunopositive for the dendrite-specific microtubule associated protean, MAP2. Ultrastructural studies showed a small percentage (8%) of lesions were derived from myelinated axons, although none were immunohistochemically labelled with antibodies to the tau protein. Staining with the astrocyte-specific markers GFAP, S-100 and vimentin yielded equivocal results, but did not support a major role for astrocytes in lesion formation. The histological profile matches that seen in some other well characterized types of spongiform degeneration.
AB - Observations from ultrastructural and immunohistochemical studies suggest that spongiform lesions in the gerbil cochlear nucleus are derived principally from dendrites. Almost one-fifth of the lesion profiles examined ultrastructurally exhibited synaptic contacts with axon terminals. In addition, approximately 80% of lesions are immunopositive for the dendrite-specific microtubule associated protean, MAP2. Ultrastructural studies showed a small percentage (8%) of lesions were derived from myelinated axons, although none were immunohistochemically labelled with antibodies to the tau protein. Staining with the astrocyte-specific markers GFAP, S-100 and vimentin yielded equivocal results, but did not support a major role for astrocytes in lesion formation. The histological profile matches that seen in some other well characterized types of spongiform degeneration.
UR - https://www.scopus.com/pages/publications/0030838824
U2 - 10.1023/A:1018593710530
DO - 10.1023/A:1018593710530
M3 - Article
C2 - 9352448
AN - SCOPUS:0030838824
SN - 0300-4864
VL - 26
SP - 625
EP - 635
JO - Journal of Neurocytology
JF - Journal of Neurocytology
IS - 9
ER -