TY - GEN
T1 - Spinal Noradrenergic Alpha-2 Receptors Mediate the Antinociceptive Effects of Therapeutic Intraspinal Microstimulation
AU - Lucas-Romero, Javier
AU - Bandres, Maria F.
AU - McPherson, Jacob G.
N1 - Publisher Copyright:
© 2024 IEEE.
PY - 2024
Y1 - 2024
N2 - This study investigates the role of noradrenergic signaling in the antinociceptive effects of intraspinal microstimulation intended to restore movement after spinal cord injury. Two rat cohorts, intact and with chronic spinal cord injury, underwent intraspinal microstimulation (ISMS), and the multiunit neuronal response to peripheral noxious stimulation was examined at the spinal cord level. The observed effects were compared with those after blocking alpha-2 adrenergic receptors using RX821002. SCI heightened the nociceptive response to pinch stimulation, but ISMS exhibited clear antinociceptive effects in both intact and injured groups. These effects were nullified by blocking alpha-2 receptors, highlighting their involvement in the depression of nociceptive processing induced by ISMS.
AB - This study investigates the role of noradrenergic signaling in the antinociceptive effects of intraspinal microstimulation intended to restore movement after spinal cord injury. Two rat cohorts, intact and with chronic spinal cord injury, underwent intraspinal microstimulation (ISMS), and the multiunit neuronal response to peripheral noxious stimulation was examined at the spinal cord level. The observed effects were compared with those after blocking alpha-2 adrenergic receptors using RX821002. SCI heightened the nociceptive response to pinch stimulation, but ISMS exhibited clear antinociceptive effects in both intact and injured groups. These effects were nullified by blocking alpha-2 receptors, highlighting their involvement in the depression of nociceptive processing induced by ISMS.
KW - alpha-2 adrenergic receptors
KW - noradrenaline
KW - pain
KW - spinal cord injury
KW - spinal cord stimulation
UR - https://www.scopus.com/pages/publications/85214969463
U2 - 10.1109/EMBC53108.2024.10782063
DO - 10.1109/EMBC53108.2024.10782063
M3 - Conference contribution
C2 - 40039198
AN - SCOPUS:85214969463
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
BT - 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2024
Y2 - 15 July 2024 through 19 July 2024
ER -