Spinal MR findings in neurofibromatosis types 1 and 2

J. C. Egelhoff, D. J. Bates, J. S. Ross, A. D. Rothner, B. H. Cohen, A. D. Elster

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Purpose: To evaluate the frequency and nature of spinal pathology, the frequency of clinically silent lesions, and the potential benefit of screening spinal MR in neurofibromatosis patients. Patients and Methods: 28 neurofibromatosis type-1 (NF-1) patients and nine neurofibromatosis type-2 (NF-2) patients were studied with postcontrast spinal MR imaging. Results: NF-1: One patient had a biopsy-proven low-grade glioma; five patients, intradural, extramedullary masses (N = 23); one patient, extradural masses (N = 2) (neurofibromas); 16 patients had bony abnormalities; and three patients thecal sac abnormalities. NF-2: Five patients demonstrated intramedullary masses (five/eight ependymomas); nine patients, intradural, extramedullary masses (meningiomas, schwannomas); and four patients, bony abnormalities. Eight/10 NF-1 and four/nine NF-2 patients had asymptomatic masses. Conclusion: Intradural disease is common, often asymptomatic, and often presents at a young age in NF-1 and NF-2 patients. Because of the propensity to develop significant asymptomatic as well as symptomatic intradural disease, screening of the entire spine with MR is recommended in both NF-1 and NF-2 patients.

Original languageEnglish
Pages (from-to)1071-1082
Number of pages12
JournalAmerican Journal of Neuroradiology
Issue number4
StatePublished - 1992


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