Spinal cord tissue affects ensheathing cell proliferation and apoptosis

Adele Woodhouse, Adele J. Vincent, Marie A. Kozel, Roger S. Chung, Phil M.E. Waite, James C. Vickers, Adrian K. West, Meng Inn Chuah

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


This study investigates proliferation and apoptosis of olfactory ensheathing cells in cocultures with spinal cord tissue. Proliferation of ensheathing cells was significantly increased when cocultured with expiants from uninjured spinal cord, and spinal cord that had been subjected to chronic contusion or chronic needle stab injury, but not to acute needle stab injury. Proliferation rate was highest in cocultures with chronically stabbed cord tissue. Contaminating (p75NGFR-negative) cells in the cultures showed a significantly higher proliferation rate than ensheathing cells. Apoptosis of ensheathing cells was significantly increased in cocultures with acutely stabbed spinal cord expiants compared with chronically contused spinal cord expiants. These results suggest that delaying transplantation after spinal cord injury may be beneficial to ensheathing cell survival.

Original languageEnglish
Pages (from-to)737-740
Number of pages4
Issue number7
StatePublished - May 12 2005


  • Contusion
  • Olfactory ensheathing cells
  • Proliferation
  • Spinal cord injury
  • Stab wounds


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