TY - JOUR
T1 - Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin
AU - Laidlaw, Brian J.
AU - Gray, Elizabeth E.
AU - Zhang, Yang
AU - Ramírez-Valle, Francisco
AU - Cyster, Jason G.
N1 - Publisher Copyright:
© 2019 Laidlaw et al.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Maintenance of a population of IL-17–committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood. Here, we find that sphingosine-1phosphate receptor 2 (S1PR2) acts in a cell-intrinsic manner to oppose γδ T cell migration from the dermis to the skin draining lymph node (dLN). Migration of dermal γδ T cells to the dLN under steady-state conditions occurs in an S1PR1-dependent manner. S1PR1 and CD69 are reciprocally expressed on dermal γδ T cells, with loss of CD69 associated with increased S1PR1 expression and enhanced migration to the dLN. γδ T cells lacking both S1PR2 and CD69 are impaired in their maintenance within the dermis. These findings provide a mechanism for how IL-17+ γδ T cells establish residence within the dermis and identify a role for S1PR2 in restraining the egress of tissue-resident lymphocytes.
AB - Maintenance of a population of IL-17–committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood. Here, we find that sphingosine-1phosphate receptor 2 (S1PR2) acts in a cell-intrinsic manner to oppose γδ T cell migration from the dermis to the skin draining lymph node (dLN). Migration of dermal γδ T cells to the dLN under steady-state conditions occurs in an S1PR1-dependent manner. S1PR1 and CD69 are reciprocally expressed on dermal γδ T cells, with loss of CD69 associated with increased S1PR1 expression and enhanced migration to the dLN. γδ T cells lacking both S1PR2 and CD69 are impaired in their maintenance within the dermis. These findings provide a mechanism for how IL-17+ γδ T cells establish residence within the dermis and identify a role for S1PR2 in restraining the egress of tissue-resident lymphocytes.
UR - http://www.scopus.com/inward/record.url?scp=85068800398&partnerID=8YFLogxK
U2 - 10.1084/jem.20190114
DO - 10.1084/jem.20190114
M3 - Article
C2 - 31160320
AN - SCOPUS:85068800398
SN - 0022-1007
VL - 216
SP - 1487
EP - 1496
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 7
ER -