Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive

Chih Hao Chang, Gwendalyn J. Randolph

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

An established role of sphingosine 1-phosphate receptor-1 in T cells is to guide their exit from lymph nodes. Reporting in Nature, Mendoza et al. (2017) now show that lymphatic endothelial sphingosine 1-phosphate signals through sphingosine 1-phosphate receptor-1 to prevent mitochondria degradation and thereby support survival of naive T cells. An established role of sphingosine 1-phosphate receptor-1 in T cells is to guide their exit from lymph nodes. Reporting in Nature, Mendoza et al. (2017) now show that lymphatic endothelial sphingosine 1-phosphate signals through sphingosine 1-phosphate receptor-1 to prevent mitochondria degradation and thereby support survival of naive T cells.

Original languageEnglish
Pages (from-to)576-578
Number of pages3
JournalDevelopmental cell
Volume41
Issue number6
DOIs
StatePublished - Jun 19 2017

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