Spectrum of Pleiotropic Effects of Statins in Heart Failure

Nitin Mathur, Kumudha Ramasubbu, Douglas L. Mann

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The syndrome of heart failure is characterized by increased levels of circulating inflammatory mediators, which have been implicated in the pathogenesis of heart failure. Recently, a number of studies have suggested that statins may exert salutary effects in patients who have heart failure by virtue of their pleiotropic (non-lipid lowering) actions. This article focuses on the non-lipid lowering effects of statins, with an emphasis on the anti-inflammatory properties of these agents.

Original languageEnglish
Pages (from-to)153-161
Number of pages9
JournalHeart Failure Clinics
Volume4
Issue number2
DOIs
StatePublished - Apr 2008
Externally publishedYes

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