Spectrum of Eye Disease Caused by Methicillin-Resistant Staphylococcus Aureus

Julie Freidlin, Nisha Acharya, Thomas M. Lietman, Vicky Cevallos, John P. Whitcher, Todd P. Margolis

Research output: Contribution to journalArticlepeer-review

118 Scopus citations


Purpose: To compare the clinical features and antibiotic susceptibility of ocular methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). Design: Cross-sectional study. Methods: The Proctor clinical laboratory database was reviewed to identify all ocular isolates of S. aureus collected between July 1, 1998 and July 31, 2006. Results: Of 915 S. aureus isolates, there were 88 MRSA isolates in 41 different patients. The proportion MRSA increased from 4.1% in 1998 to 1999 to 16.7% in 2005 to 2006. A total of 78.0% of patients with MRSA had blepharoconjunctivitis, 2.4% had cellulitis, 2.4% had dacryocystitis, 14.6% had keratitis, and 2.4% had endophthalmitis. The diagnoses associated with MSSA were not statistically different. A total of 63.6% of MRSA isolates were sensitive to bacitracin, 100% to vancomycin, 14.8% to ciprofloxacin, 14.8% to erythromycin, 97.7% to sulfisoxazole, and 93.2% to tetracycline. Conclusions: MRSA has become a more common ocular pathogen but, as with MSSA, causes mild disease. MRSA should be treated with vancomycin.

Original languageEnglish
Pages (from-to)313-315
Number of pages3
JournalAmerican journal of ophthalmology
Issue number2
StatePublished - Aug 2007


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