TY - JOUR
T1 - Spectrum of Eye Disease Caused by Methicillin-Resistant Staphylococcus Aureus
AU - Freidlin, Julie
AU - Acharya, Nisha
AU - Lietman, Thomas M.
AU - Cevallos, Vicky
AU - Whitcher, John P.
AU - Margolis, Todd P.
N1 - Funding Information:
This study was supported by the F. I. Proctor Foundation, San Francisco, California. The authors indicate no financial conflict of interest. Involved in design and conduct of study (J.F., N.A., T.P.M.); collection (J.F., V.C.); management (J.F., J.P.W., T.P.M.); analysis (J.F., N.A., T.M.L., T.P.M.); interpretation of data (J.F., N.A., T.M.L., T.P.M.); preparation (J.F., N.A., T.P.M.); and review and approval of the manuscript (J.F., N.A., T.P.M.). This study was approved by the University of California, San Francisco, Committee on Human Research.
PY - 2007/8
Y1 - 2007/8
N2 - Purpose: To compare the clinical features and antibiotic susceptibility of ocular methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). Design: Cross-sectional study. Methods: The Proctor clinical laboratory database was reviewed to identify all ocular isolates of S. aureus collected between July 1, 1998 and July 31, 2006. Results: Of 915 S. aureus isolates, there were 88 MRSA isolates in 41 different patients. The proportion MRSA increased from 4.1% in 1998 to 1999 to 16.7% in 2005 to 2006. A total of 78.0% of patients with MRSA had blepharoconjunctivitis, 2.4% had cellulitis, 2.4% had dacryocystitis, 14.6% had keratitis, and 2.4% had endophthalmitis. The diagnoses associated with MSSA were not statistically different. A total of 63.6% of MRSA isolates were sensitive to bacitracin, 100% to vancomycin, 14.8% to ciprofloxacin, 14.8% to erythromycin, 97.7% to sulfisoxazole, and 93.2% to tetracycline. Conclusions: MRSA has become a more common ocular pathogen but, as with MSSA, causes mild disease. MRSA should be treated with vancomycin.
AB - Purpose: To compare the clinical features and antibiotic susceptibility of ocular methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). Design: Cross-sectional study. Methods: The Proctor clinical laboratory database was reviewed to identify all ocular isolates of S. aureus collected between July 1, 1998 and July 31, 2006. Results: Of 915 S. aureus isolates, there were 88 MRSA isolates in 41 different patients. The proportion MRSA increased from 4.1% in 1998 to 1999 to 16.7% in 2005 to 2006. A total of 78.0% of patients with MRSA had blepharoconjunctivitis, 2.4% had cellulitis, 2.4% had dacryocystitis, 14.6% had keratitis, and 2.4% had endophthalmitis. The diagnoses associated with MSSA were not statistically different. A total of 63.6% of MRSA isolates were sensitive to bacitracin, 100% to vancomycin, 14.8% to ciprofloxacin, 14.8% to erythromycin, 97.7% to sulfisoxazole, and 93.2% to tetracycline. Conclusions: MRSA has become a more common ocular pathogen but, as with MSSA, causes mild disease. MRSA should be treated with vancomycin.
UR - http://www.scopus.com/inward/record.url?scp=34447621598&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2007.03.032
DO - 10.1016/j.ajo.2007.03.032
M3 - Article
C2 - 17659970
AN - SCOPUS:34447621598
SN - 0002-9394
VL - 144
SP - 313
EP - 315
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 2
ER -