TY - JOUR
T1 - Spectroscopic characterization of bendazac and benzydamine
T2 - Possible photochemical modes of action
AU - Jez, Joseph M.
AU - Vanderkooi, Jane M.
AU - Laties, Alan M.
N1 - Funding Information:
This work was supported by NIH Grant GM34448 awarded to J.M.V. and by Research to Prevent Blindness, New York, NY and The National Retinitis Pigmentosa Foundation, Inc. to A.M.L.
PY - 1996/4/16
Y1 - 1996/4/16
N2 - The involvement of near-UV light in cataract development suggests that potential anti-cataract drugs may display unusual spectroscopic properties. As bendazac impedes certain effects associated with lens opacification, we have characterized the singlet and triplet states of bendazac and its analog, benzydamine, by fluorescence and phosphorescence methods. These compounds have much shorter triplet state lifetimes compared to the triplet state lifetimes observed in proteins. Our results raise the possibility that the photoprotective action of these compounds may result from their ability to dissipate energy through the triplet state. We propose alternative modes for the photoprotective actions of these compounds.
AB - The involvement of near-UV light in cataract development suggests that potential anti-cataract drugs may display unusual spectroscopic properties. As bendazac impedes certain effects associated with lens opacification, we have characterized the singlet and triplet states of bendazac and its analog, benzydamine, by fluorescence and phosphorescence methods. These compounds have much shorter triplet state lifetimes compared to the triplet state lifetimes observed in proteins. Our results raise the possibility that the photoprotective action of these compounds may result from their ability to dissipate energy through the triplet state. We propose alternative modes for the photoprotective actions of these compounds.
UR - http://www.scopus.com/inward/record.url?scp=0029918867&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1996.0584
DO - 10.1006/bbrc.1996.0584
M3 - Article
C2 - 8619844
AN - SCOPUS:0029918867
SN - 0006-291X
VL - 221
SP - 266
EP - 270
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -