Spectral changes in cortical surface potentials during motor movement

Kai J. Miller, Eric C. Leuthardt, Gerwin Schalk, Rajesh P.N. Rao, Nicholas R. Anderson, Daniel W. Moran, John W. Miller, Jeffrey G. Ojemann

Research output: Contribution to journalArticlepeer-review

516 Scopus citations

Abstract

In the first large study of its kind, we quantified changes in electrocorticographic signals associated with motor movement across 22 subjects with subdural electrode arrays placed for identification of seizure foci. Patients underwent a 5-7 d monitoring period with array placement, before seizure focus resection, and during this time they participated in the study. An interval-based motor-repetition task produced consistent and quantifiable spectral shifts that were mapped on a Talairach-standardized template cortex. Maps were created independently for a high-frequency band (HFB) (76-100 Hz) and a low-frequency band (LFB) (8-32 Hz) for several different movement modalities in each subject. The power in relevant electrodes consistently decreased in the LFB with movement, whereas the power in the HFB consistently increased. In addition, the HFB changes were more focal than the LFB changes. Sites of power changes corresponded to stereotactic locations in sensorimotor cortex and to the results of individual clinical electrical cortical mapping. Sensorimotor representation was found to be somatotopic, localized in stereotactic space to rolandic cortex, and typically followed the classic homunculus with limited extrarolandic representation.

Original languageEnglish
Pages (from-to)2424-2432
Number of pages9
JournalJournal of Neuroscience
Volume27
Issue number9
DOIs
StatePublished - Feb 28 2007

Keywords

  • Cortical spectra
  • Electrocorticography (ECoG)
  • Homunculus
  • Mapping
  • Motor
  • Somatotopy

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