Speckle-modulating optical coherence tomography in living mice and humans

Orly Liba, Matthew D. Lew, Elliott D. Sorelle, Rebecca Dutta, Debasish Sen, Darius M. Moshfeghi, Steven Chu, Adam De La Zerda

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo. As a consequence, OCT is susceptible to coherent noise (speckle noise), which imposes significant limitations on its diagnostic capabilities. Here we show speckle-modulating OCT (SM-OCT), a method based purely on light manipulation that virtually eliminates speckle noise originating from a sample. SM-OCT accomplishes this by creating and averaging an unlimited number of scans with uncorrelated speckle patterns without compromising spatial resolution. Using SM-OCT, we reveal small structures in the tissues of living animals, such as the inner stromal structure of a live mouse cornea, the fine structures inside the mouse pinna, and sweat ducts and Meissner's corpuscle in the human fingertip skin - features that are otherwise obscured by speckle noise when using conventional OCT or OCT with current state of the art speckle reduction methods.

Original languageEnglish
Article number15845
JournalNature communications
Volume8
DOIs
StatePublished - Jun 20 2017

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