@article{9e3ef8112c6e4bf4af76916a2030cdd2,
title = "Specimen Collection for Translational Studies in Hidradenitis Suppurativa",
abstract = "Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by painful nodules, sinus tracts, and scars occurring predominantly in intertriginous regions. The prevalence of HS is currently 0.053–4%, with a predominance in African-American women and has been linked to low socioeconomic status. The majority of the reported literature is retrospective, population based, epidemiologic studies. In this regard, there is a need to establish a repository of biospecimens, which represent appropriate gender and racial demographics amongst HS patients. These efforts will diminish knowledge gaps in understanding the disease pathophysiology. Hence, we sought to outline a step-by-step protocol detailing how we established our HS biobank to facilitate the formation of other HS tissue banks. Equipping researchers with carefully detailed processes for collection of HS specimens would accelerate the accumulation of well-organized human biological material. Over time, the scientific community will have access to a broad range of HS tissue biospecimens, ultimately leading to more rigorous basic and translational research. Moreover, an improved understanding of the pathophysiology is necessary for the discovery of novel therapies for this debilitating disease. We aim to provide high impact translational research methodology for cutaneous biology research and foster multidisciplinary collaboration and advancement of our understanding of cutaneous diseases.",
author = "Byrd, {A. S.} and Y. Dina and Okoh, {U. J.} and Quartey, {Q. Q.} and C. Carmona-Rivera and Williams, {D. W.} and Kerns, {M. L.} and Miller, {R. J.} and L. Petukhova and Naik, {H. B.} and Barnes, {L. A.} and Shipman, {W. D.} and Caffrey, {J. A.} and Sacks, {J. M.} and Milner, {S. M.} and O. Aliu and Broderick, {K. P.} and D. Kim and H. Liu and Dillen, {C. A.} and R. Ahn and Frew, {J. W.} and Kaplan, {M. J.} and S. Kang and Garza, {L. A.} and Miller, {L. S.} and A. Alavi and Lowes, {M. A.} and Okoye, {G. A.}",
note = "Funding Information: We kindly thank Pierre Coulombe, PhD, Avi Rosenberg, MD, PhD, Marco Delsante, PhD, Sean Zhang, MD, PhD, Ben Larman, PhD, Jelani Zarif, PhD, Karen Brown, PhD, Marc Edwards, PhD, Jonathan Reichner, PhD, Nate Archer, PhD, Janielle Maynard, PhD, Carrie Cox, RN, MS, Ellie Meeder, Valerie Spatafore, Nora Viloria, the JHUSOM Reference Histology and Immunopathology Cores, Fatimah Jackson, PhD (Howard University), and Robert Jackson, PhD (University of Maryland) for their insight and assistance. Also, we are grateful for the Andrew W. Mellon Foundation, and the Office of Faculty Development in the Office of the Provost at Howard University for supporting the 2019 Junior Faculty Writing and Creative Works Summer Academy. Dr. Byrd was a participant in the Johns Hopkins Ethnic Skin Fellowship, which was supported in part by a grant from the Valeant Pharmaceuticals. The company was not involved in the conception of the research idea, conduct of the experiments, and the writing of this manuscript. Supported in part by the Intramural Research Program, NIAMS/NIH, ZIA AR041199, the Johns Hopkins School of Medicine Physician Scientist Training Program (PSTP), the Danby Hidradenitis Suppurativa Foundation Research Grant, and the American Academy of Dermatology Diversity Mentoring Program. Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41598-019-48226-w",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
number = "1",
}