Specificity, free energy and information content in protein-DNA interactions

Gary D. Stormo, Dana S. Fields

Research output: Contribution to journalReview articlepeer-review

273 Scopus citations

Abstract

Site-specific DNA-protein interactions can be studied using experimental and computational methods. Experimental approaches typically analyze a protein-DNA interaction by measuring the free energy of binding under a variety of conditions. Computational methods focus on alignments of known binding sites for a protein, and, from these alignments, make estimates of the binding energy. Understanding the relationship between these two perspectives, and finding ways to improve both, is a major challenge of modern molecular biology.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalTrends in biochemical sciences
Volume23
Issue number3
DOIs
StatePublished - Mar 1 1998

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