Specific stimulation and inhibition of renal prostaglandin release by angiotensin analogs

P. Needleman, A. H. Kauffman, J. R. Douglas, E. M. Johnson, G. R. Marshall

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

The isolated Krebs perfused rabbit kidney released prostaglandin like substance (PLS) when treated with angiotensin II, angiotensin I, epinephrine, or bradykinin. Angiotensin I appears to induce renal PLS release without substantial conversion to the octapeptide. The specific competitive angiotensin antagonist [8 cysteine] angiotensin II (as well as other angiotensin antagonists) was found to be capable of inhibiting both the direct actions of angiotensin II on isolated smooth muscle preparations and the stimulation of specific renal receptor sites by angiotensin II to evoke PLS release. The angiotensin antagonists did not block PLS release by epinephrine or bradykinin, whereas indomethacin blocked PLS release induced both by AII and by epinephrine. The potential therapeutic use of angiotensin antagonists in the treatment of hemorrhagic shock is discussed.

Original languageEnglish
Pages (from-to)1415-1419
Number of pages5
JournalAmerican Journal of Physiology
Volume224
Issue number6
StatePublished - Dec 1 1973

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