TY - JOUR
T1 - Specific innervation of muscle fiber types in a developmentally polyinnervated muscle
AU - Gordon, Herman
AU - Van Essen, David C.
N1 - Funding Information:
We thank W. Thompson and A. Rowlerson for valuable discussions, C. Shotwell for technical help, .and K. Bell and C. Oto for typing. H.G. thanks the National Scienc’e Foundation for a graduate fellowship and the National Institute of General Medical Sciences for a National Research Award (1T 32 GM0773’7). We are also grateful for support from the Pew Memorial Trust, the Sloan Foundation, and BRSG Grant RR07003 awarded by the Biomedical Research Support Grant Program, Division of Research Resources, National Institutes of Health.
PY - 1985/9
Y1 - 1985/9
N2 - In neonatal rabbit soleus muscle, different motor units were found to contract with widely varying time courses. Analysis of these data suggest that individual motor units are largely homogeneous for muscle fiber type despite the presence of extensive polyinnervation at birth. We suggest that (1) neonatal motor neurons are effectively differentiated into specific types insofar as they preferentially innervate muscle fibers which give rise to different contraction times, and (2) muscle fibers begin their physiological differentiation into twitch types while still polyinnervated. Possible mechanisms underlying the development of a specific pattern of neuromuscular innervation are discussed.
AB - In neonatal rabbit soleus muscle, different motor units were found to contract with widely varying time courses. Analysis of these data suggest that individual motor units are largely homogeneous for muscle fiber type despite the presence of extensive polyinnervation at birth. We suggest that (1) neonatal motor neurons are effectively differentiated into specific types insofar as they preferentially innervate muscle fibers which give rise to different contraction times, and (2) muscle fibers begin their physiological differentiation into twitch types while still polyinnervated. Possible mechanisms underlying the development of a specific pattern of neuromuscular innervation are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0022405698&partnerID=8YFLogxK
U2 - 10.1016/0012-1606(85)90433-6
DO - 10.1016/0012-1606(85)90433-6
M3 - Article
C2 - 3161768
AN - SCOPUS:0022405698
SN - 0012-1606
VL - 111
SP - 42
EP - 50
JO - Developmental Biology
JF - Developmental Biology
IS - 1
ER -