Specific in vivo binding of 77Br-brombenperidol in rat brain

S. M. Moerlein, G. Stöcklin

Research output: Contribution to journalArticlepeer-review

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The in vivo binding of the radiobrominated neuroleptic brombenperidol in rat brain was studied. The accumulation of the radiolabeled neuroleptic was high in the striatum and relatively low in the cerebellum, cortex, and blood. Striatal binding of brombenperidol was saturable and displaced by subsequent administration of benperidol. The rationale for the development of 75Br-brombenperidol as a radiopharmaceutical for the non-invasive imaging of cerebral dopamine receptor areas is presented.

Original languageEnglish
Pages (from-to)1357-1363
Number of pages7
JournalLife Sciences
Issue number13
StatePublished - Sep 24 1984


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