Specialization and evolution of endogenous small RNA pathways

Elisabeth J. Chapman, James C. Carrington

Research output: Contribution to journalReview articlepeer-review

579 Scopus citations

Abstract

The specificity of RNA silencing is conferred by small RNA guides that are processed from structured RNA or dsRNA. The core components for small RNA biogenesis and effector functions have proliferated and specialized in eukaryotic lineages, resulting in diversified pathways that control expression of endogenous and exogenous genes, invasive elements and viruses, and repeated sequences. Deployment of small RNA pathways for spatiotemporal regulation of the transcriptome has shaped the evolution of eukaryotic genomes and contributed to the complexity of multicellular organisms.

Original languageEnglish
Pages (from-to)884-896
Number of pages13
JournalNature Reviews Genetics
Volume8
Issue number11
DOIs
StatePublished - Nov 2007

Fingerprint

Dive into the research topics of 'Specialization and evolution of endogenous small RNA pathways'. Together they form a unique fingerprint.

Cite this