TY - JOUR
T1 - Specialization and evolution of endogenous small RNA pathways
AU - Chapman, Elisabeth J.
AU - Carrington, James C.
N1 - Funding Information:
We thank members of the Carrington laboratory for productive discussions. E.J.C. was supported in part by a P.F. and Nellie Buck Yerex Fellowship. Research in the J.C.C. laboratory was supported by grants from the US National Institutes of Health, the US National Science Foundation and the US Department of Agriculture.
PY - 2007/11
Y1 - 2007/11
N2 - The specificity of RNA silencing is conferred by small RNA guides that are processed from structured RNA or dsRNA. The core components for small RNA biogenesis and effector functions have proliferated and specialized in eukaryotic lineages, resulting in diversified pathways that control expression of endogenous and exogenous genes, invasive elements and viruses, and repeated sequences. Deployment of small RNA pathways for spatiotemporal regulation of the transcriptome has shaped the evolution of eukaryotic genomes and contributed to the complexity of multicellular organisms.
AB - The specificity of RNA silencing is conferred by small RNA guides that are processed from structured RNA or dsRNA. The core components for small RNA biogenesis and effector functions have proliferated and specialized in eukaryotic lineages, resulting in diversified pathways that control expression of endogenous and exogenous genes, invasive elements and viruses, and repeated sequences. Deployment of small RNA pathways for spatiotemporal regulation of the transcriptome has shaped the evolution of eukaryotic genomes and contributed to the complexity of multicellular organisms.
UR - http://www.scopus.com/inward/record.url?scp=35348996554&partnerID=8YFLogxK
U2 - 10.1038/nrg2179
DO - 10.1038/nrg2179
M3 - Review article
C2 - 17943195
AN - SCOPUS:35348996554
SN - 1471-0056
VL - 8
SP - 884
EP - 896
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 11
ER -