Spatiotemporally Controlled Photoresponsive Hydrogels: Design and Predictive Modeling from Processing through Application

Hongyuan Zhu, Haiqian Yang, Yufei Ma, Tian Jian Lu, Feng Xu, Guy M. Genin, Min Lin

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations

Abstract

Photoresponsive hydrogels (PRHs) are soft materials whose mechanical and chemical properties can be tuned spatially and temporally with relative ease. Both photo-crosslinkable and photodegradable hydrogels find utility in a range of biomedical applications that require tissue-like properties or programmable responses. Progress in engineering with PRHs is facilitated by the development of theoretical tools that enable optimization of their photochemistry, polymer matrices, nanofillers, and architecture. This review brings together models and design principles that enable key applications of PRHs in tissue engineering, drug delivery, and soft robotics, and highlights ongoing challenges in both modeling and application.

Original languageEnglish
Article number2000639
JournalAdvanced Functional Materials
Volume30
Issue number32
DOIs
StatePublished - Aug 1 2020

Keywords

  • hydrogels
  • mechanical properties
  • models
  • photo-crosslinking
  • photodegradation

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