Spatiotemporal Quantification of Cerebral Blood Flow during Functional Activation in Rat Somatosensory Cortex Using Laser-Speckle Flowmetry

Turgut Durduran, Mark G. Burnett, Guoqiang Yu, Chao Zhou, Daisuke Furuya, Arjun G. Yodh, John A. Detre, Joel H. Greenberg

Research output: Contribution to journalArticlepeer-review

152 Scopus citations

Abstract

Laser-speckle flowmetry was used to characterize activation flow coupling after electrical somatosensory stimulation of forepaw and hindpaw in the rat. Quantification of functional activation was made with high transverse spatial (μm) and temporal (msec) resolution. Different activation levels and duration of stimulation were quantitatively investigated, and were in good agreement with previous laser-Doppler measurements. Interestingly, the magnitude but not the overall shape of the response was found to scale with stimulus amplitude and the distance from the activation centroid. The results provide new insights about the spatial characteristics of cerebral blood flow response to functional activation, and the method should lead to improved understanding of the coupling of neuronal activity and hemodynamics under normal and pathologic conditions.

Original languageEnglish
Pages (from-to)518-525
Number of pages8
JournalJournal of Cerebral Blood Flow and Metabolism
Volume24
Issue number5
DOIs
StatePublished - May 2004

Keywords

  • Activation flow coupling
  • Cerebral blood flow
  • Flowmetry
  • Functional imaging
  • Laser speckle
  • Somatosensory cortex

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