TY - JOUR
T1 - Spatial Transcriptomics
T2 - Integrating Morphology and Molecular Mechanisms of Kidney Diseases
AU - Isnard, Pierre
AU - Humphreys, Benjamin D.
N1 - Publisher Copyright:
© 2025 American Society for Investigative Pathology
PY - 2025/1
Y1 - 2025/1
N2 - The recent arrival of high-resolution spatial transcriptomics (ST) technologies is generating a veritable revolution in life sciences, enabling biomolecules to be measured in their native spatial context. By integrating morphology and molecular biology, ST technologies offer the potential of improving the understanding of tissue biology and disease and may also provide meaningful clinical insights. This review describes the main ST technologies currently available and the computational analysis for data interpretation and visualization, and illustrate their scientific and potential medical interest in the context of kidney disease. Finally, we discuss the perspectives and challenges of these booming new technologies.
AB - The recent arrival of high-resolution spatial transcriptomics (ST) technologies is generating a veritable revolution in life sciences, enabling biomolecules to be measured in their native spatial context. By integrating morphology and molecular biology, ST technologies offer the potential of improving the understanding of tissue biology and disease and may also provide meaningful clinical insights. This review describes the main ST technologies currently available and the computational analysis for data interpretation and visualization, and illustrate their scientific and potential medical interest in the context of kidney disease. Finally, we discuss the perspectives and challenges of these booming new technologies.
UR - http://www.scopus.com/inward/record.url?scp=85212083886&partnerID=8YFLogxK
U2 - 10.1016/j.ajpath.2024.06.012
DO - 10.1016/j.ajpath.2024.06.012
M3 - Review article
C2 - 39097166
AN - SCOPUS:85212083886
SN - 0002-9440
VL - 195
SP - 23
EP - 39
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 1
ER -