TY - JOUR
T1 - SOX10 and GATA3 in Adenoid Cystic Carcinoma and Polymorphous Adenocarcinoma
AU - Adkins, Brian D.
AU - Geromes, Ariana
AU - Zhang, Lily Y.
AU - Chernock, Rebecca
AU - Kimmelshue, Katherine
AU - Lewis, James
AU - Ely, Kim
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Differentiating between adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAC) can be difficult on small biopsies and cytologic specimens. As such, further characterization of their immunophenotype may aid in distinction. Previous studies have found AdCC to be SOX10+/GATA3 variable and PAC to be GATA3 negative. SOX10 expression in PAC has, as yet, not been established. We performed GATA3 and SOX10 immunohistochemistry on whole sections of 25 cases each of AdCC and PAC (including both classic PAC and the cribriform variant) to assess whether these markers are of diagnostic utility in distinguishing between these entities. SOX10 was found to be positive in 100% of PAC and AdCC whereas GATA 3 was immunoreactive in 45% of AdCCs and 20% of PAC. While this is the first series to compare SOX10 and GATA3 staining in these two tumor types, their frequent expression and similar staining patterns render them of limited value in discriminating between these neoplasms.
AB - Differentiating between adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAC) can be difficult on small biopsies and cytologic specimens. As such, further characterization of their immunophenotype may aid in distinction. Previous studies have found AdCC to be SOX10+/GATA3 variable and PAC to be GATA3 negative. SOX10 expression in PAC has, as yet, not been established. We performed GATA3 and SOX10 immunohistochemistry on whole sections of 25 cases each of AdCC and PAC (including both classic PAC and the cribriform variant) to assess whether these markers are of diagnostic utility in distinguishing between these entities. SOX10 was found to be positive in 100% of PAC and AdCC whereas GATA 3 was immunoreactive in 45% of AdCCs and 20% of PAC. While this is the first series to compare SOX10 and GATA3 staining in these two tumor types, their frequent expression and similar staining patterns render them of limited value in discriminating between these neoplasms.
KW - Adenoid cystic carcinoma
KW - GATA3
KW - Polymorphous adenocarcinoma
KW - SOX10
KW - Salivary gland
UR - https://www.scopus.com/pages/publications/85073780055
U2 - 10.1007/s12105-019-01046-w
DO - 10.1007/s12105-019-01046-w
M3 - Article
C2 - 31222589
AN - SCOPUS:85073780055
SN - 1936-055X
VL - 14
SP - 406
EP - 411
JO - Head and Neck Pathology
JF - Head and Neck Pathology
IS - 2
ER -