TY - JOUR
T1 - Sonographic depiction of microvessel perfusion
T2 - Principles and potential
AU - Fleischer, Arthur C.
AU - Niermann, Kenneth J.
AU - Donnelly, Edwin F.
AU - Yankeelov, Thomas E.
AU - Canniff, Kathryn M.
AU - Hallahan, Dennis E.
AU - Rothenberg, Mace E.
PY - 2004/11
Y1 - 2004/11
N2 - Objective. To provide an overview of the technical aspects and potential clinical applications of microvessel perfusion as depicted by microbubble-enhanced sonography. Methods. Sonographic depiction of microvessel perfusion was obtained by microbubble-enhanced sonography. This technique was used for imaging in vivo murine tumors and was correlated with magnetic resonance and fluorodeoxyglucose autoradiography. Sonographic estimation of microvessel perfusion used parameters derived from time-activity curves. Results. Preliminary data indicate that accurate and reproducible quantification of microvessel perfusion is possible with the use of microbubble-enhanced sonography. Conclusions. Microbubble-enhanced sonography can depict microvessel perfusion. This technique has several potential clinical applications, including assessment of tumor blood flow and changes that occur with treatment.
AB - Objective. To provide an overview of the technical aspects and potential clinical applications of microvessel perfusion as depicted by microbubble-enhanced sonography. Methods. Sonographic depiction of microvessel perfusion was obtained by microbubble-enhanced sonography. This technique was used for imaging in vivo murine tumors and was correlated with magnetic resonance and fluorodeoxyglucose autoradiography. Sonographic estimation of microvessel perfusion used parameters derived from time-activity curves. Results. Preliminary data indicate that accurate and reproducible quantification of microvessel perfusion is possible with the use of microbubble-enhanced sonography. Conclusions. Microbubble-enhanced sonography can depict microvessel perfusion. This technique has several potential clinical applications, including assessment of tumor blood flow and changes that occur with treatment.
KW - Microbubble-enhanced sonography
KW - Microvessel perfusion
KW - Tumor neovascularity
UR - http://www.scopus.com/inward/record.url?scp=6944227670&partnerID=8YFLogxK
U2 - 10.7863/jum.2004.23.11.1499
DO - 10.7863/jum.2004.23.11.1499
M3 - Review article
C2 - 15498915
AN - SCOPUS:6944227670
SN - 0278-4297
VL - 23
SP - 1499
EP - 1506
JO - Journal of Ultrasound in Medicine
JF - Journal of Ultrasound in Medicine
IS - 11
ER -