Sonographic depiction of microvessel perfusion: Principles and potential

Arthur C. Fleischer, Kenneth J. Niermann, Edwin F. Donnelly, Thomas E. Yankeelov, Kathryn M. Canniff, Dennis E. Hallahan, Mace E. Rothenberg

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Objective. To provide an overview of the technical aspects and potential clinical applications of microvessel perfusion as depicted by microbubble-enhanced sonography. Methods. Sonographic depiction of microvessel perfusion was obtained by microbubble-enhanced sonography. This technique was used for imaging in vivo murine tumors and was correlated with magnetic resonance and fluorodeoxyglucose autoradiography. Sonographic estimation of microvessel perfusion used parameters derived from time-activity curves. Results. Preliminary data indicate that accurate and reproducible quantification of microvessel perfusion is possible with the use of microbubble-enhanced sonography. Conclusions. Microbubble-enhanced sonography can depict microvessel perfusion. This technique has several potential clinical applications, including assessment of tumor blood flow and changes that occur with treatment.

Original languageEnglish
Pages (from-to)1499-1506
Number of pages8
JournalJournal of Ultrasound in Medicine
Issue number11
StatePublished - Nov 2004


  • Microbubble-enhanced sonography
  • Microvessel perfusion
  • Tumor neovascularity


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