Some general considerations about the clinicopathologic aspects of soft tissue tumors in children and adolescents

Cheryl M. Coffin, Rita Alaggio, Louis P. Dehner

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Soft tissue tumors in children and adolescents are an important group of neoplasms, pseudoneoplasms, and tumefactive malformations with some distinctive clinicopathologic, genetic, syndromic, and therapeutic implications. In addition to the basic pathologic examination, there is the availability of diagnostic adjuncts in various settings based upon the histopathologic features that facilitate and/or corroborate a diagnosis. Immunohistochemistry, cytogenetics, molecular genetics, and an everincreasing array of new technologies are available to address specific diagnostic questions and even potential therapeutic strategies. This review focuses upon some of the unique aspects of soft tissue tumors in children, including the classification, approach to the diagnosis, grading, clinical and pathologic staging, therapy-related changes, pathogenesis, and risk factors.

Original languageEnglish
Pages (from-to)11-25
Number of pages15
JournalPediatric and Developmental Pathology
Volume15
Issue numberSUPPL. 1
DOIs
StatePublished - Mar 28 2012

Keywords

  • Adolescent and young adult cancer
  • Childhood cancer
  • Soft tissue pathology
  • Soft tissue sarcoma
  • Soft tissue tumors

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