TY - JOUR
T1 - Some general considerations about the clinicopathologic aspects of soft tissue tumors in children and adolescents
AU - Coffin, Cheryl M.
AU - Alaggio, Rita
AU - Dehner, Louis P.
PY - 2012
Y1 - 2012
N2 - Soft tissue tumors in children and adolescents are an important group of neoplasms, pseudoneoplasms, and tumefactive malformations with some distinctive clinicopathologic, genetic, syndromic, and therapeutic implications. In addition to the basic pathologic examination, there is the availability of diagnostic adjuncts in various settings based upon the histopathologic features that facilitate and/or corroborate a diagnosis. Immunohistochemistry, cytogenetics, molecular genetics, and an everincreasing array of new technologies are available to address specific diagnostic questions and even potential therapeutic strategies. This review focuses upon some of the unique aspects of soft tissue tumors in children, including the classification, approach to the diagnosis, grading, clinical and pathologic staging, therapy-related changes, pathogenesis, and risk factors.
AB - Soft tissue tumors in children and adolescents are an important group of neoplasms, pseudoneoplasms, and tumefactive malformations with some distinctive clinicopathologic, genetic, syndromic, and therapeutic implications. In addition to the basic pathologic examination, there is the availability of diagnostic adjuncts in various settings based upon the histopathologic features that facilitate and/or corroborate a diagnosis. Immunohistochemistry, cytogenetics, molecular genetics, and an everincreasing array of new technologies are available to address specific diagnostic questions and even potential therapeutic strategies. This review focuses upon some of the unique aspects of soft tissue tumors in children, including the classification, approach to the diagnosis, grading, clinical and pathologic staging, therapy-related changes, pathogenesis, and risk factors.
KW - Adolescent and young adult cancer
KW - Childhood cancer
KW - Soft tissue pathology
KW - Soft tissue sarcoma
KW - Soft tissue tumors
UR - http://www.scopus.com/inward/record.url?scp=84858774171&partnerID=8YFLogxK
U2 - 10.2350/11-08-1081-PB.1
DO - 10.2350/11-08-1081-PB.1
M3 - Review article
C2 - 22375909
AN - SCOPUS:84858774171
SN - 1093-5266
VL - 15
SP - 11
EP - 25
JO - Pediatric and Developmental Pathology
JF - Pediatric and Developmental Pathology
IS - SUPPL. 1
ER -