Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

Gemma Texidó, Heinz Jacobs, Myriam Meiering, Ralf Kühn, Jürgen Roes, Werner Müller, Susan Gilfillan, Hiroshi Fujiwara, Hitoshi Kikutani, Nobuaki Yoshida, Ryuichi Amakawa, Christophe Benoist, Diane Mathis, Tadamitsu Kishimoto, Tak W. Mak, Klaus Rajewsky

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We show through sequence analysis of rearranged immunoglobulin variable (Ig-V) region genes from memory B cells of mouse mutants generated by gene targeting that terminal deoxynucleotidyl transferase, CD23, interleukin-4, IgD and CD30 are dispensable for somatic hypermutation.

Original languageEnglish
Pages (from-to)1966-1969
Number of pages4
JournalEuropean Journal of Immunology
Volume26
Issue number8
DOIs
StatePublished - 1996

Keywords

  • CD23
  • Hypermutation
  • IgD
  • Interleukin-4
  • Terminal deoxynucleotidyl transferase

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