TY - JOUR
T1 - Somatic control of germ cell development in Caenorhabditis elegans
AU - Clifford, Robert
AU - Francis, Ross
AU - Schedl, Tim
PY - 1994/2
Y1 - 1994/2
N2 - Germ cell development in Caenorhabditis elegans involves three processes: a shift from the mitotic to the meiotic cell cycle; the adoption of a male or female sexual identity; and differentiation into a functional gamete. All three aspects of germline development appear to be regulated, at least in part, by the soma. We discuss cell ablation, genetic and molecular studies that have shed light on the nature of the signal transduction systems mediating intercellular communication between germline and somatic tissues of the nematode.
AB - Germ cell development in Caenorhabditis elegans involves three processes: a shift from the mitotic to the meiotic cell cycle; the adoption of a male or female sexual identity; and differentiation into a functional gamete. All three aspects of germline development appear to be regulated, at least in part, by the soma. We discuss cell ablation, genetic and molecular studies that have shed light on the nature of the signal transduction systems mediating intercellular communication between germline and somatic tissues of the nematode.
KW - C. elegans/germline-soma interactions/proliferation/sex determination/gametogenesis
UR - http://www.scopus.com/inward/record.url?scp=38149145002&partnerID=8YFLogxK
U2 - 10.1006/sedb.1994.1004
DO - 10.1006/sedb.1994.1004
M3 - Article
AN - SCOPUS:38149145002
SN - 1044-5781
VL - 5
SP - 21
EP - 30
JO - Seminars in Developmental Biology
JF - Seminars in Developmental Biology
IS - 1
ER -