TY - JOUR
T1 - Solving the Conundrum of Eosinophils in Alloimmunity
AU - Lynch, Cherie Alissa
AU - Guo, Yizhan
AU - Mei, Zhongcheng
AU - Kreisel, Daniel
AU - Gelman, Andrew E.
AU - Jacobsen, Elizabeth A.
AU - Krupnick, Alexander Sasha
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - Eosinophils are bone-marrow-derived granulocytes known for their ability to facilitate clearance of parasitic infections and their association with asthma and other inflammatory diseases. The purpose of this review is to discuss the currently available human observational and animal experimental data linking eosinophils to the immunologic response in solid organ transplantation. First, we present observational human studies that demonstrate a link between transplantation and eosinophils yet were unable to define the exact role of this cell population. Next, we describe published experimental models and demonstrate a defined mechanistic role of eosinophils in downregulating the alloimmune response to murine lung transplants. The overall summary of this data suggests that further studies are needed to define the role of eosinophils in multiple solid organ allografts and points to the possibility of manipulating this cell population to improve graft survival.
AB - Eosinophils are bone-marrow-derived granulocytes known for their ability to facilitate clearance of parasitic infections and their association with asthma and other inflammatory diseases. The purpose of this review is to discuss the currently available human observational and animal experimental data linking eosinophils to the immunologic response in solid organ transplantation. First, we present observational human studies that demonstrate a link between transplantation and eosinophils yet were unable to define the exact role of this cell population. Next, we describe published experimental models and demonstrate a defined mechanistic role of eosinophils in downregulating the alloimmune response to murine lung transplants. The overall summary of this data suggests that further studies are needed to define the role of eosinophils in multiple solid organ allografts and points to the possibility of manipulating this cell population to improve graft survival.
UR - http://www.scopus.com/inward/record.url?scp=85135224729&partnerID=8YFLogxK
U2 - 10.1097/TP.0000000000004030
DO - 10.1097/TP.0000000000004030
M3 - Review article
C2 - 34966103
AN - SCOPUS:85135224729
SN - 0041-1337
VL - 106
SP - 1538
EP - 1547
JO - Transplantation
JF - Transplantation
IS - 8
ER -