TY - JOUR
T1 - Solid/solution-phase annulation reagents
T2 - Single-step synthesis of cyclic amine derivatives
AU - Dolle, Roland E.
AU - MacLeod, Calum
AU - Martinez-Teipel, Blanca
AU - Barker, William
AU - Seida, Pamela R.
AU - Herbertz, Torsten
PY - 2005/9/4
Y1 - 2005/9/4
N2 - Spanning the diversity gap: The conversion of primary amines into cyclic derivatives is achieved by using a family of amine-derivatizing reagents, termed SPAn reagents (see scheme). The reagents, which require no further chemical manipulation or activation, are used to prepare discrete compounds or a library collection of diverse heterocycles. SPAn reagents have application in finding new lead compounds and the development of structure-activity relationships. (Equation Presented).
AB - Spanning the diversity gap: The conversion of primary amines into cyclic derivatives is achieved by using a family of amine-derivatizing reagents, termed SPAn reagents (see scheme). The reagents, which require no further chemical manipulation or activation, are used to prepare discrete compounds or a library collection of diverse heterocycles. SPAn reagents have application in finding new lead compounds and the development of structure-activity relationships. (Equation Presented).
KW - Amines
KW - Annulation
KW - Combinatorial chemistry
KW - Cycloaddition
KW - Heterocycles
UR - http://www.scopus.com/inward/record.url?scp=24944487205&partnerID=8YFLogxK
U2 - 10.1002/anie.200501665
DO - 10.1002/anie.200501665
M3 - Article
C2 - 16078285
AN - SCOPUS:24944487205
SN - 1433-7851
VL - 44
SP - 5830
EP - 5833
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 36
ER -