Solid/solution-phase annulation reagents: Single-step synthesis of cyclic amine derivatives

Roland E. Dolle, Calum MacLeod, Blanca Martinez-Teipel, William Barker, Pamela R. Seida, Torsten Herbertz

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Spanning the diversity gap: The conversion of primary amines into cyclic derivatives is achieved by using a family of amine-derivatizing reagents, termed SPAn reagents (see scheme). The reagents, which require no further chemical manipulation or activation, are used to prepare discrete compounds or a library collection of diverse heterocycles. SPAn reagents have application in finding new lead compounds and the development of structure-activity relationships. (Equation Presented).

Original languageEnglish
Pages (from-to)5830-5833
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number36
StatePublished - Sep 4 2005


  • Amines
  • Annulation
  • Combinatorial chemistry
  • Cycloaddition
  • Heterocycles


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