Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents

Amruta R. Poreddy, Otto F. Schall, Garland R. Marshall, Colin Ratledge, Urszula Slomczynska

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A solid-phase approach for the total synthesis of methyl carboxymycobactins 1a-d, with an on-resin cyclization leading to azopine 5 as the key step, was developed. The iron-affinity of these compounds was assessed by a competitive sulfoxine-binding assay, and antimycobacterial activity was tested against the growth of Mycobacterium avium.

Original languageEnglish
Pages (from-to)2553-2556
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number15
DOIs
StatePublished - Aug 4 2003

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