Abstract
A personal review by the first graduate student of Professor R. Bruce Merrifield of the evolution of solid-phase synthesis and its acceptance by various subsets of the chemistry community. Solid-phase synthesis, as currently practised in the synthesis of biopolymers, combinatorial solid-phase organic chemistry, synthesis of natural products, catalyst selection, chemical ligation and materials development, has proven a paradigm shift for the chemistry community.
Original language | English |
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Pages (from-to) | 534-544 |
Number of pages | 11 |
Journal | Journal of Peptide Science |
Volume | 9 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2003 |
Keywords
- Combinatorial chemistry
- Deletion sequences
- John M. Stewart
- R. Bruce Merrifield
- SPOC
- SPPS
- Solid-phase organic chemistry
- Solid-phase peptide chemistry
- Truncation