A personal review by the first graduate student of Professor R. Bruce Merrifield of the evolution of solid-phase synthesis and its acceptance by various subsets of the chemistry community. Solid-phase synthesis, as currently practised in the synthesis of biopolymers, combinatorial solid-phase organic chemistry, synthesis of natural products, catalyst selection, chemical ligation and materials development, has proven a paradigm shift for the chemistry community.
- Combinatorial chemistry
- Deletion sequences
- John M. Stewart
- R. Bruce Merrifield
- Solid-phase organic chemistry
- Solid-phase peptide chemistry