Solid-phase synthesis: A paradigm shift

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22 Scopus citations


A personal review by the first graduate student of Professor R. Bruce Merrifield of the evolution of solid-phase synthesis and its acceptance by various subsets of the chemistry community. Solid-phase synthesis, as currently practised in the synthesis of biopolymers, combinatorial solid-phase organic chemistry, synthesis of natural products, catalyst selection, chemical ligation and materials development, has proven a paradigm shift for the chemistry community.

Original languageEnglish
Pages (from-to)534-544
Number of pages11
JournalJournal of Peptide Science
Issue number9
StatePublished - Sep 1 2003


  • Combinatorial chemistry
  • Deletion sequences
  • John M. Stewart
  • R. Bruce Merrifield
  • SPOC
  • SPPS
  • Solid-phase organic chemistry
  • Solid-phase peptide chemistry
  • Truncation


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