Solid bolus swallows during high-resolution manometry complement multiple rapid swallows in predicting symptoms following antireflux surgery

Garrett Greenan, Benjamin D. Rogers, Daniel Sifrim, C. Prakash Gyawali

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Solid bolus swallows (SBS) assess esophageal peristalsis on high-resolution manometry (HRM). It remains unknown if increase in contraction vigor (contraction reserve) following SBS (SBS-CR) provides information similar to that observed following multiple rapid swallows (MRS-CR). Methods: Clinical and HRM data from adult patients (n = 96, age 58.2 years, 61.5% female) undergoing esophageal testing prior to anti-reflux surgery (ARS) were analyzed if both MRS and SBS were available, and compared to similar data from healthy asymptomatic volunteers (n = 18, age 27.5 years, 55.6% female). Patients reported esophageal symptoms before and after ARS using 5-point Likert scales evaluating symptom frequency and severity; scores for each patient were averaged to determine global symptoms. Distal contractile integral (DCI) from single swallows was compared to MRS DCI and SBS DCI; the ratio of single swallow DCI to MRS DCI or SBS DCI ≥1 determined the presence of contraction reserve. Key Results: Multiple rapid swallows CR was concordant with SBS CR in 55.6% of healthy volunteers, 100% of absent contractility, 100% of ineffective esophageal motility (IEM) and 56.9% without IEM. Correlation between MRS DCI and SBS DCI was highest when IEM criteria were met (Spearman's rho 0.998). While neither MRS CR nor SBS CR presence differed by presenting symptoms or global symptom score at baseline, post-ARS global symptom burden was highest in the absence of both MRS CR and SBS CR, especially in patients with esophageal hypomotility using Chicago Classification version 4.0 criteria (p = 0.03). Conclusions & Inferences: Multiple rapid swallows and SBS are complementary in predicting post-ARS symptom burden.

Original languageEnglish
JournalNeurogastroenterology and Motility
DOIs
StateAccepted/In press - 2022

Keywords

  • contraction reserve
  • high-resolution manometry
  • multiple rapid swallow
  • solid bolus swallow

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