TY - JOUR
T1 - Soft, bioresorbable coolers for reversible conduction block of peripheral nerves
AU - Reeder, Jonathan T.
AU - Xie, Zhaoqian
AU - Yang, Quansan
AU - Seo, Min Ho
AU - Yan, Ying
AU - Deng, Yujun
AU - Jinkins, Katherine R.
AU - Krishnan, Siddharth R.
AU - Liu, Claire
AU - McKay, Shannon
AU - Patnaude, Emily
AU - Johnson, Alexandra
AU - Zhao, Zichen
AU - Kim, Moon Joo
AU - Xu, Yameng
AU - Huang, Ivy
AU - Avila, Raudel
AU - Felicelli, Christopher
AU - Ray, Emily
AU - Guo, Xu
AU - Ray, Wilson Z.
AU - Huang, Yonggang
AU - MacEwan, Matthew R.
AU - Rogers, John A.
N1 - Publisher Copyright:
© 2022 American Association for the Advancement of Science. All rights reserved.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Implantable devices capable of targeted and reversible blocking of peripheral nerve activity may provide alternatives to opioids for treating pain. Local cooling represents an attractive means for on-demand elimination of pain signals, but traditional technologies are limited by rigid, bulky form factors; imprecise cooling; and requirements for extraction surgeries. Here, we introduce soft, bioresorbable, microfluidic devices that enable delivery of focused, minimally invasive cooling power at arbitrary depths in living tissues with real-time temperature feedback control. Construction with water-soluble, biocompatible materials leads to dissolution and bioresorption as a mechanism to eliminate unnecessary device load and risk to the patient without additional surgeries. Multiweek in vivo trials demonstrate the ability to rapidly and precisely cool peripheral nerves to provide local, on-demand analgesia in rat models for neuropathic pain.
AB - Implantable devices capable of targeted and reversible blocking of peripheral nerve activity may provide alternatives to opioids for treating pain. Local cooling represents an attractive means for on-demand elimination of pain signals, but traditional technologies are limited by rigid, bulky form factors; imprecise cooling; and requirements for extraction surgeries. Here, we introduce soft, bioresorbable, microfluidic devices that enable delivery of focused, minimally invasive cooling power at arbitrary depths in living tissues with real-time temperature feedback control. Construction with water-soluble, biocompatible materials leads to dissolution and bioresorption as a mechanism to eliminate unnecessary device load and risk to the patient without additional surgeries. Multiweek in vivo trials demonstrate the ability to rapidly and precisely cool peripheral nerves to provide local, on-demand analgesia in rat models for neuropathic pain.
UR - http://www.scopus.com/inward/record.url?scp=85133262486&partnerID=8YFLogxK
U2 - 10.1126/science.abl8532
DO - 10.1126/science.abl8532
M3 - Article
C2 - 35771907
AN - SCOPUS:85133262486
SN - 0036-8075
VL - 377
SP - 109
EP - 115
JO - Science
JF - Science
IS - 6601
ER -