Abstract
Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with cystic fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance of ciprofloxacin.
| Original language | English |
|---|---|
| Article number | e00448-16 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 61 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2017 |
Keywords
- Biofilm
- Ciprofloxacin
- Fluoroquinolone
- Nitrite
- Nitrosative stress
- Pseudomonas aeruginosa