Sodium nitrite inhibits killing of Pseudomonas aeruginosa biofilms by ciprofloxacin

Anna C. Zemke; Brian R. Kocak; Jennifer M. Bomberger

doi:10.1128/AAC.00448-16

Sodium nitrite inhibits killing of Pseudomonas aeruginosa biofilms by ciprofloxacin

Anna C. Zemke
, Brian R. Kocak
, Jennifer M. Bomberger

Division of Hospital Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with cystic fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance of ciprofloxacin.

Original language	English
Article number	e00448-16
Journal	Antimicrobial agents and chemotherapy
Volume	61
Issue number	1
DOIs	https://doi.org/10.1128/AAC.00448-16
State	Published - Jan 1 2017

Keywords

Biofilm
Ciprofloxacin
Fluoroquinolone
Nitrite
Nitrosative stress
Pseudomonas aeruginosa

Access to Document

10.1128/AAC.00448-16

Cite this

@article{4670129bd6c24d688d691520bdc18b60,

title = "Sodium nitrite inhibits killing of Pseudomonas aeruginosa biofilms by ciprofloxacin",

abstract = "Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with cystic fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance of ciprofloxacin.",

keywords = "Biofilm, Ciprofloxacin, Fluoroquinolone, Nitrite, Nitrosative stress, Pseudomonas aeruginosa",

author = "Zemke, \{Anna C.\} and Kocak, \{Brian R.\} and Bomberger, \{Jennifer M.\}",

year = "2017",

month = jan,

day = "1",

doi = "10.1128/AAC.00448-16",

language = "English",

volume = "61",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

number = "1",

}

TY - JOUR

T1 - Sodium nitrite inhibits killing of Pseudomonas aeruginosa biofilms by ciprofloxacin

AU - Zemke, Anna C.

AU - Kocak, Brian R.

AU - Bomberger, Jennifer M.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with cystic fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance of ciprofloxacin.

AB - Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with cystic fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance of ciprofloxacin.

KW - Biofilm

KW - Ciprofloxacin

KW - Fluoroquinolone

KW - Nitrite

KW - Nitrosative stress

KW - Pseudomonas aeruginosa

UR - https://www.scopus.com/pages/publications/85009289937

U2 - 10.1128/AAC.00448-16

DO - 10.1128/AAC.00448-16

M3 - Article

C2 - 27799207

AN - SCOPUS:85009289937

SN - 0066-4804

VL - 61

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 1

M1 - e00448-16

ER -

Sodium nitrite inhibits killing of Pseudomonas aeruginosa biofilms by ciprofloxacin

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this