TY - JOUR
T1 - Sodium channels and transporters in the myometrium
AU - Amazu, Chinwendu
AU - Ferreira, Juan J.
AU - Santi, Celia M.
AU - England, Sarah K.
N1 - Publisher Copyright:
© 2019
PY - 2020/2
Y1 - 2020/2
N2 - In excitable cells such as neurons and cardiomyocytes, sodium influx across the plasma membrane contributes to the resting membrane potential, and sodium is the key ion for generating action potentials. In myometrial smooth muscle cells, however, the functions of sodium influx have not been fully elucidated. This review briefly discusses the contribution of Na+ pumps to myometrial excitability but given the brevity of this article, we focus on the evidence that sodium influx through various types of channels may play numerous roles in controlling myometrial excitability.
AB - In excitable cells such as neurons and cardiomyocytes, sodium influx across the plasma membrane contributes to the resting membrane potential, and sodium is the key ion for generating action potentials. In myometrial smooth muscle cells, however, the functions of sodium influx have not been fully elucidated. This review briefly discusses the contribution of Na+ pumps to myometrial excitability but given the brevity of this article, we focus on the evidence that sodium influx through various types of channels may play numerous roles in controlling myometrial excitability.
UR - http://www.scopus.com/inward/record.url?scp=85076778642&partnerID=8YFLogxK
U2 - 10.1016/j.cophys.2019.11.011
DO - 10.1016/j.cophys.2019.11.011
M3 - Review article
AN - SCOPUS:85076778642
SN - 2468-8681
VL - 13
SP - 141
EP - 144
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
ER -