TY - JOUR
T1 - Social disadvantage during pregnancy
T2 - effects on gestational age and birthweight
AU - Luby, Joan L.
AU - England, Sarah K.
AU - Barch, Deanna M.
AU - Warner, Barbara B.
AU - Rogers, Cynthia
AU - Smyser, Christopher D.
AU - Triplett, Regina
AU - Arora, Jyoti
AU - Smyser, Tara A.
AU - Slavich, George M.
AU - Zhao, Peinan
AU - Stout, Molly
AU - Herzog, Erik
AU - Miller, J. Philip
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/4
Y1 - 2023/4
N2 - Objective: Whether psychosocial adversity during pregnancy impacts fetal health outcomes at birth remains underexplored. This is a critical issue given significant social disadvantage and psychosocial stress faced by pregnant women worldwide. Study design: Measures of social disadvantage and psychological factors, and medical/reproductive and nutritional health status in pregnant women were obtained at each trimester. Using Structural Equation Modeling (SEM), we investigated the relationship of forms of adversity to each other and to infant gestational age, and birthweight. Results: Among 399 singletons, Social Disadvantage significantly predicted gestational age (p = 0.003), and residual birthweight (p = 0.006). There was a 0.4 week decrease in gestational age and a 3% decrease in birthweight for each standard deviation increase in Social Disadvantage. Conclusion: Significant negative effects of social adversity on the developing fetus were found. Notably, these effects emerged despite good prenatal care and after accounting for maternal age and medical reproductive risk factors.
AB - Objective: Whether psychosocial adversity during pregnancy impacts fetal health outcomes at birth remains underexplored. This is a critical issue given significant social disadvantage and psychosocial stress faced by pregnant women worldwide. Study design: Measures of social disadvantage and psychological factors, and medical/reproductive and nutritional health status in pregnant women were obtained at each trimester. Using Structural Equation Modeling (SEM), we investigated the relationship of forms of adversity to each other and to infant gestational age, and birthweight. Results: Among 399 singletons, Social Disadvantage significantly predicted gestational age (p = 0.003), and residual birthweight (p = 0.006). There was a 0.4 week decrease in gestational age and a 3% decrease in birthweight for each standard deviation increase in Social Disadvantage. Conclusion: Significant negative effects of social adversity on the developing fetus were found. Notably, these effects emerged despite good prenatal care and after accounting for maternal age and medical reproductive risk factors.
UR - http://www.scopus.com/inward/record.url?scp=85149879745&partnerID=8YFLogxK
U2 - 10.1038/s41372-023-01643-2
DO - 10.1038/s41372-023-01643-2
M3 - Article
C2 - 36914799
AN - SCOPUS:85149879745
SN - 0743-8346
VL - 43
SP - 477
EP - 483
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 4
ER -