Social, Behavioral, and Clinical Risk Factors Are Associated with Clonal Hematopoiesis

Corey D. Young, Aubrey K. Hubbard, Pedro F. Saint-Maurice, Irenaeus C.C. Chan, Yin Cao, Duc Tran, Kelly L. Bolton, Stephen J. Chanock, Charles E. Matthews, Steven C. Moore, Erikka Loftfield, Mitchell J. Machiela

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Risk factors including smoking, alcohol intake, chromosome risk [OR ¼ 1.17; 95% confidence interval (CI), physical activity (PA), and sleep patterns have been associated 1.09–1.25; P ¼ 8.31 X 10‐6] compared with light drinkers, with cancer risk. Clonal hematopoiesis (CH), including mosaic active males (moderate-high PA) had elevated risks of mLOY chromosomal alterations and clonal hematopoiesis of indeter- (PA category 3: OR ¼ 1.06; 95% CI, 1.03–1.08; P ¼ 7.57 X minate potential, is linked to increased hematopoietic cancer risk 10‐6), and men with high body mass index (≥40) had reduced and could be used as common preclinical intermediates for the risk of mLOY (OR ¼ 0.57; 95% CI, 0.51–0.65; P ¼ 3.30 X better understanding of associations of risk factors with rare 10‐20). Sensitivity analyses with body mass index adjustment hematologic malignancies. attenuated the effect in the mLOY–PA associations (IPAQ2: Methods: We analyzed cross-sectional data from 478,513 UK OR ¼ 1.03; 95% CI, 1.00–1.06; P ¼ 2.13 X 10‐2 and IPAQ3: Biobank participants without hematologic malignancies using OR ¼ 1.03; 95% CI, 1.01–1.06; P ¼ 7.77 X 10‐3). multivariable-adjusted analyses to assess the associations between Conclusions: Our study reveals associations between social lifestyle factors and CH types. deprivation, smoking, and alcohol consumption and CH risk, Results: Smoking was reinforced as a potent modifiable risk suggesting that these exposures could contribute to common factor for multiple CH types, with dose-dependent relation- types of CH and potentially rare hematologic cancers. ships persisting after cessation. Males in socially deprived Impact : This study underscores the impact of lifestyle factors areas of England had a lower risk of mosaic loss of chromo- on CH frequency, emphasizing social, behavioral, and clinical some Y (mLOY), females with moderate/high alcohol con- influences and the importance of sociobehavioral contexts when sumption (2–3 drinks/day) had increased mosaic loss of the X investigating CH risk factors.

Original languageEnglish
Pages (from-to)1423-1432
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume33
Issue number11
DOIs
StatePublished - Nov 1 2024

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