SnoN signaling in proliferating cells and postmitotic neurons

Shirin Bonni, Azad Bonni

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

The transcriptional regulator SnoN plays a fundamental role as a modulator of transforming growth factor beta (TGFβ)-induced signal transduction and biological responses. In recent years, novel functions of SnoN have been discovered in both TGFβ-dependent and TGFβ-independent settings in proliferating cells and postmitotic neurons. Accumulating evidence suggests that SnoN plays a dual role as a corepressor or coactivator of TGFβ-induced transcription. Accordingly, SnoN exerts oncogenic or tumor-suppressive effects in epithelial tissues. At the cellular level, SnoN antagonizes or mediates the ability of TGFβ to induce cell cycle arrest in a cell-type specific manner. SnoN also exerts key effects on epithelial-mesenchymal transition (EMT), with implications in cancer biology. Recent studies have expanded SnoN functions to postmitotic neurons, where SnoN orchestrates key aspects of neuronal development in the mammalian brain, from axon growth and branching to neuronal migration and positioning. In this review, we will highlight our understanding of SnoN biology at the crossroads of cancer biology and neurobiology.

Original languageEnglish
Pages (from-to)1977-1983
Number of pages7
JournalFEBS Letters
Volume586
Issue number14
DOIs
StatePublished - Jul 4 2012

Keywords

  • Axon growth
  • Cancer
  • Neuronal migration and positioning
  • SnoN
  • TGFβ-signaling and response
  • Transcriptional regulator

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