@article{27b2f64df1aa43efac74444665ac1c14,
title = "Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation",
abstract = "Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides a potential new link between chromatin dynamics and neoplastic disease.",
keywords = "Cancer Smyd3, Epigenetics, Lysine, Methylation, Oncogene, Oncology",
author = "{van Aller}, {Glenn S.} and Nicolas Reynoird and Olena Barbash and Michael Huddleston and Shichong Liu and Zmoos, {Anne Flore} and Patrick McDevitt and Robert Sinnamon and Le, {Bao Chau} and Gloria Mas and Roland Annan and Julien Sage and Garcia, {Benjamin A.} and Tummino, {Peter J.} and Or Gozani and Kruger, {Ryan G.}",
note = "Funding Information: and Linda Myers for technical support. This work was supported in part by grants to O.G. (NIH R01 GM079641 and GlaxoSmithKline), to B.A.G. (DP2OD007447 and NSF CAREER Award), and J.S. and O.G. (CIRM RB1-01385). N.R. was funded by a Fondation pour la Recherche Medicale Postdoctoral Fellowship. O.G. is a recipient of an Ellison Senior Scholar in Aging Award.",
year = "2012",
month = apr,
doi = "10.4161/epi.19506",
language = "English",
volume = "7",
pages = "340--343",
journal = "Epigenetics",
issn = "1559-2294",
number = "4",
}