Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation

Glenn S. van Aller, Nicolas Reynoird, Olena Barbash, Michael Huddleston, Shichong Liu, Anne Flore Zmoos, Patrick McDevitt, Robert Sinnamon, Bao Chau Le, Gloria Mas, Roland Annan, Julien Sage, Benjamin A. Garcia, Peter J. Tummino, Or Gozani, Ryan G. Kruger

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

Smyd3 is a lysine methyltransferase implicated in chromatin and cancer regulation. Here we show that Smyd3 catalyzes histone H4 methylation at lysine 5 (H4K5me). This novel histone methylation mark is detected in diverse cell types and its formation is attenuated by depletion of Smyd3 protein. Further, Smyd3-driven cancer cell phenotypes require its enzymatic activity. Thus, Smyd3, via H4K5 methylation, provides a potential new link between chromatin dynamics and neoplastic disease.

Original languageEnglish
Pages (from-to)340-343
Number of pages4
JournalEpigenetics
Volume7
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • Cancer Smyd3
  • Epigenetics
  • Lysine
  • Methylation
  • Oncogene
  • Oncology

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