Smoking history, intensity, and duration and risk of prostate cancer recurrence among men with prostate cancer who received definitive treatment

Saira Khan, Shivani Thakkar, Bettina Drake

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To examine the association of smoking history and multiple measures of smoking intensity and duration with risk of biochemical recurrence in men treated for prostate cancer. Methods: We conducted a prospective cohort study of 1641 men (773 ever-smokers) treated with radical prostatectomy or radiation between 2003 and 2010. The association between ever-smoking and risk of biochemical recurrence was examined using Cox Proportional Hazards models with adjustment for confounders. Among ever-smokers, we further assessed the association between multiple measures of smoking duration and intensity and risk of biochemical recurrence. Results: In the full cohort, we observed no association between ever-smoking and risk of biochemical recurrence. However, among ever-smokers, a smoking duration of greater than or equal to 10 years was significantly associated with biochemical recurrence (hazard ratio: 2.32, 95% confidence interval: 1.01, 5.33). Our results also suggested that greater than or equal to 10 pack-years of smoking may be associated with an increased risk of biochemical recurrence (hazard ratio: 1.75, 95% confidence interval: 0.97, 3.15). No association was observed between packs smoked per day or years since smoking cessation (among former smokers) and risk of biochemical recurrence. Conclusion: Smoking duration is a significant predicator of biochemical recurrence among men with prostate cancer who are current or former smokers.

Original languageEnglish
Pages (from-to)4-10
Number of pages7
JournalAnnals of Epidemiology
Volume38
DOIs
StatePublished - Oct 2019

Keywords

  • Biochemical recurrence
  • Pack-years
  • Packs per day
  • Prostate cancer
  • Smoking
  • Smoking cessation
  • Smoking duration

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