TY - JOUR
T1 - Smoking history, intensity, and duration and risk of prostate cancer recurrence among men with prostate cancer who received definitive treatment
AU - Khan, Saira
AU - Thakkar, Shivani
AU - Drake, Bettina
N1 - Funding Information:
S.K. was supported by T32190194 (PI: Colditz) and DOD Prostate Cancer Research Program grant PC170130 . B.D. was supported by 1U54CA153460-01. S.K. and B.D. were supported by the Foundation for Barnes-Jewish Hospital and Siteman Cancer Center . This project was also supported, in part, by funds from the St. Louis Men's Group Against Cancer . This content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH .
Funding Information:
The authors thank the participants of the Washington University PCPC for their important contributions. S.K. was supported by T32190194 (PI: Colditz) and DOD Prostate Cancer Research Program grant PC170130. B.D. was supported by 1U54CA153460-01. S.K. and B.D. were supported by the Foundation for Barnes-Jewish Hospital and Siteman Cancer Center. This project was also supported, in part, by funds from the St. Louis Men's Group Against Cancer. This content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/10
Y1 - 2019/10
N2 - Purpose: To examine the association of smoking history and multiple measures of smoking intensity and duration with risk of biochemical recurrence in men treated for prostate cancer. Methods: We conducted a prospective cohort study of 1641 men (773 ever-smokers) treated with radical prostatectomy or radiation between 2003 and 2010. The association between ever-smoking and risk of biochemical recurrence was examined using Cox Proportional Hazards models with adjustment for confounders. Among ever-smokers, we further assessed the association between multiple measures of smoking duration and intensity and risk of biochemical recurrence. Results: In the full cohort, we observed no association between ever-smoking and risk of biochemical recurrence. However, among ever-smokers, a smoking duration of greater than or equal to 10 years was significantly associated with biochemical recurrence (hazard ratio: 2.32, 95% confidence interval: 1.01, 5.33). Our results also suggested that greater than or equal to 10 pack-years of smoking may be associated with an increased risk of biochemical recurrence (hazard ratio: 1.75, 95% confidence interval: 0.97, 3.15). No association was observed between packs smoked per day or years since smoking cessation (among former smokers) and risk of biochemical recurrence. Conclusion: Smoking duration is a significant predicator of biochemical recurrence among men with prostate cancer who are current or former smokers.
AB - Purpose: To examine the association of smoking history and multiple measures of smoking intensity and duration with risk of biochemical recurrence in men treated for prostate cancer. Methods: We conducted a prospective cohort study of 1641 men (773 ever-smokers) treated with radical prostatectomy or radiation between 2003 and 2010. The association between ever-smoking and risk of biochemical recurrence was examined using Cox Proportional Hazards models with adjustment for confounders. Among ever-smokers, we further assessed the association between multiple measures of smoking duration and intensity and risk of biochemical recurrence. Results: In the full cohort, we observed no association between ever-smoking and risk of biochemical recurrence. However, among ever-smokers, a smoking duration of greater than or equal to 10 years was significantly associated with biochemical recurrence (hazard ratio: 2.32, 95% confidence interval: 1.01, 5.33). Our results also suggested that greater than or equal to 10 pack-years of smoking may be associated with an increased risk of biochemical recurrence (hazard ratio: 1.75, 95% confidence interval: 0.97, 3.15). No association was observed between packs smoked per day or years since smoking cessation (among former smokers) and risk of biochemical recurrence. Conclusion: Smoking duration is a significant predicator of biochemical recurrence among men with prostate cancer who are current or former smokers.
KW - Biochemical recurrence
KW - Pack-years
KW - Packs per day
KW - Prostate cancer
KW - Smoking
KW - Smoking cessation
KW - Smoking duration
UR - http://www.scopus.com/inward/record.url?scp=85072516129&partnerID=8YFLogxK
U2 - 10.1016/j.annepidem.2019.08.011
DO - 10.1016/j.annepidem.2019.08.011
M3 - Article
C2 - 31563295
AN - SCOPUS:85072516129
VL - 38
SP - 4
EP - 10
JO - Annals of Epidemiology
JF - Annals of Epidemiology
SN - 1047-2797
ER -