TY - JOUR
T1 - Smoking history, intensity, and duration and risk of prostate cancer recurrence among men with prostate cancer who received definitive treatment
AU - Khan, Saira
AU - Thakkar, Shivani
AU - Drake, Bettina
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/10
Y1 - 2019/10
N2 - Purpose: To examine the association of smoking history and multiple measures of smoking intensity and duration with risk of biochemical recurrence in men treated for prostate cancer. Methods: We conducted a prospective cohort study of 1641 men (773 ever-smokers) treated with radical prostatectomy or radiation between 2003 and 2010. The association between ever-smoking and risk of biochemical recurrence was examined using Cox Proportional Hazards models with adjustment for confounders. Among ever-smokers, we further assessed the association between multiple measures of smoking duration and intensity and risk of biochemical recurrence. Results: In the full cohort, we observed no association between ever-smoking and risk of biochemical recurrence. However, among ever-smokers, a smoking duration of greater than or equal to 10 years was significantly associated with biochemical recurrence (hazard ratio: 2.32, 95% confidence interval: 1.01, 5.33). Our results also suggested that greater than or equal to 10 pack-years of smoking may be associated with an increased risk of biochemical recurrence (hazard ratio: 1.75, 95% confidence interval: 0.97, 3.15). No association was observed between packs smoked per day or years since smoking cessation (among former smokers) and risk of biochemical recurrence. Conclusion: Smoking duration is a significant predicator of biochemical recurrence among men with prostate cancer who are current or former smokers.
AB - Purpose: To examine the association of smoking history and multiple measures of smoking intensity and duration with risk of biochemical recurrence in men treated for prostate cancer. Methods: We conducted a prospective cohort study of 1641 men (773 ever-smokers) treated with radical prostatectomy or radiation between 2003 and 2010. The association between ever-smoking and risk of biochemical recurrence was examined using Cox Proportional Hazards models with adjustment for confounders. Among ever-smokers, we further assessed the association between multiple measures of smoking duration and intensity and risk of biochemical recurrence. Results: In the full cohort, we observed no association between ever-smoking and risk of biochemical recurrence. However, among ever-smokers, a smoking duration of greater than or equal to 10 years was significantly associated with biochemical recurrence (hazard ratio: 2.32, 95% confidence interval: 1.01, 5.33). Our results also suggested that greater than or equal to 10 pack-years of smoking may be associated with an increased risk of biochemical recurrence (hazard ratio: 1.75, 95% confidence interval: 0.97, 3.15). No association was observed between packs smoked per day or years since smoking cessation (among former smokers) and risk of biochemical recurrence. Conclusion: Smoking duration is a significant predicator of biochemical recurrence among men with prostate cancer who are current or former smokers.
KW - Biochemical recurrence
KW - Pack-years
KW - Packs per day
KW - Prostate cancer
KW - Smoking
KW - Smoking cessation
KW - Smoking duration
UR - http://www.scopus.com/inward/record.url?scp=85072516129&partnerID=8YFLogxK
U2 - 10.1016/j.annepidem.2019.08.011
DO - 10.1016/j.annepidem.2019.08.011
M3 - Article
C2 - 31563295
AN - SCOPUS:85072516129
SN - 1047-2797
VL - 38
SP - 4
EP - 10
JO - Annals of Epidemiology
JF - Annals of Epidemiology
ER -