Smartphone-based fundus photography for screening of plus-disease retinopathy of prematurity

Tapan P. Patel, Michael T. Aaberg, Yannis M. Paulus, Philip Lieu, Vaidehi S. Dedania, Cynthia X. Qian, Cagri G. Besirli, Todd Margolis, Daniel A. Fletcher, Tyson N. Kim

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background: Inadequate screening of treatment-warranted retinopathy of prematurity (ROP) can lead to devastating visual outcomes. Especially in resource-poor communities, the use of an affordable, portable, and easy to use smartphone-based non-contact fundus photography device may prove useful for screening for high-risk ROP. This study evaluates the feasibility of screening for high-risk ROP using a novel smartphone-based fundus photography device, RetinaScope. Methods: Retinal images were obtained using RetinaScope on a cohort of prematurely born infants during routine examinations for ROP. Images were reviewed by two masked graders who determined the image quality, the presence or absence of plus disease, and whether there was retinopathy that met predefined criteria for referral. The agreement between image-based assessments was compared to the gold standard indirect ophthalmoscopic assessment. Results: Fifty-four eyes of 27 infants were included. A wide-field fundus photograph was obtained using RetinaScope. Image quality was acceptable or excellent in 98% and 95% of cases. There was substantial agreement between the gold standard and photographic assessment of presence or absence of plus disease (Cohen’s κ = 0.85). Intergrader agreement on the presence of any retinopathy in photographs was also high (κ = 0.92). Conclusions: RetinaScope can capture digital retinal photographs of prematurely born infants with good image quality for grading of plus disease.

Original languageEnglish
Pages (from-to)2579-2585
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number11
StatePublished - Nov 1 2019


  • Fundus photography
  • Plus disease
  • Retinopathy of prematurity
  • Smartphone
  • Telemedicine


Dive into the research topics of 'Smartphone-based fundus photography for screening of plus-disease retinopathy of prematurity'. Together they form a unique fingerprint.

Cite this