TY - JOUR
T1 - Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide
AU - the ENIGMA Stroke RecoveryWorking Group
AU - Liew, Sook Lei
AU - Zavaliangos-Petropulu, Artemis
AU - Schweighofer, Nicolas
AU - Jahanshad, Neda
AU - Lang, Catherine E.
AU - Lohse, Keith R.
AU - Banaj, Nerisa
AU - Barisano, Giuseppe
AU - Baugh, Lee A.
AU - Bhattacharya, Anup K.
AU - Bigjahan, Bavrina
AU - Borich, Michael R.
AU - Boyd, Lara A.
AU - Brodtmann, Amy
AU - Buetefisch, Cathrin M.
AU - Byblow, Winston D.
AU - Cassidy, Jessica M.
AU - Charalambous, Charalambos C.
AU - Ciullo, Valentina
AU - Conforto, Adriana B.
AU - Craddock, Richard C.
AU - Dula, Adrienne N.
AU - Egorova, Natalia
AU - Feng, Wuwei
AU - Fercho, Kelene A.
AU - Gregory, Chris M.
AU - Hanlon, Colleen A.
AU - Hayward, Kathryn S.
AU - Holguin, Jess A.
AU - Hordacre, Brenton
AU - Hwang, Darryl H.
AU - Kautz, Steven A.
AU - Khlif, Mohamed Salah
AU - Kim, Bokkyu
AU - Kim, Hosung
AU - Kuceyeski, Amy
AU - Lo, Bethany
AU - Liu, Jingchun
AU - Lin, David
AU - Lotze, Martin
AU - MacIntosh, Bradley J.
AU - Margetis, John L.
AU - Mohamed, Feroze B.
AU - Nordvik, Jan Egil
AU - Petoe, Matthew A.
AU - Piras, Fabrizio
AU - Raju, Sharmila
AU - Ramos-Murguialday, Ander
AU - Revill, Kate P.
AU - Roberts, Pamela
AU - Robertson, Andrew D.
AU - Schambra, Heidi M.
AU - Seo, Na Jin
AU - Shiroish, Mark S.
AU - Soekadar, Surjo R.
AU - Spalletta, Gianfranco
AU - Stinear, Cathy M.
AU - Suri, Anisha
AU - Tang, Wai Kwong
AU - Thielman, Gregory T.
AU - Thijs, Vincent N.
AU - Vecchio, Daniela
AU - Ward, Nick S.
AU - Westlye, Lars T.
AU - Winstein, Carolee J.
AU - Wittenberg, George F.
AU - Wong, Kristin A.
AU - Yu, Chunshui
AU - Wolf, Steven L.
AU - Cramer, Steven C.
AU - Thompson, Paul M.
AU - Gallaguet, Adrià Bermudo
AU - Brown, Truman
AU - Cloutier, Alison
AU - Cole, James
AU - Aguayo, Rosalia Dacosta
AU - DiCarlo, Julie
AU - Dimyan, Michael
AU - Domin, Martin
AU - Donnellly, Miranda
AU - Edwardson, Matthew
AU - Ermer, Elsa
AU - Etherton, Mark
AU - Ferris, Jennifer
AU - Geranmayeh, Fatemeh
AU - Hadidchi, Shahram
AU - Hayes, Leticia
AU - Jamison, Keith
AU - Juliano, Julia
AU - Margulies, Daniel
AU - Mataro, Maria
AU - McGregor, Keith
AU - Olafson, Emily
AU - Perera-LLuna, Alexandre
AU - Phillips, Aaron
AU - Rondina, Jane
AU - Rost, Natalia
AU - Sanossian, Nerses
AU - Sepehrband, Farshid
AU - Shiroishi, Mark
AU - Simon, Julia
AU - Srivastava, Shraddha
AU - Stewart, Jill
AU - Taga, Myriam
AU - Kwong, Waitang
AU - Thomopoulos, Sophia
AU - Warach, Steven
AU - Werden, Emilio
AU - Wiest, Roland
N1 - Publisher Copyright:
© The Author(s) (2021).
PY - 2021
Y1 - 2021
N2 - Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI brain scans and behavioural data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behaviour to non-lesioned subcortical volumes (Bonferroni-corrected, P<0.004). We tested subacute (≤90 days) and chronic (≥180 days) stroke subgroups separately, with exploratory analyses in early stroke (≤21 days) and across all time. Sub-analyses in chronic stroke were also performed based on class of sensorimotor deficits (impairment, activity limitations) and side of lesioned hemisphere. Worse sensorimotor behaviour was associated with a smaller ipsilesional thalamic volume in both early (n=179; d=0.68) and subacute (n=274, d=0.46) stroke. In chronic stroke (n=404), worse sensorimotor behaviour was associated with smaller ipsilesional putamen (d=0.52) and nucleus accumbens (d=0.39) volumes, and a larger ipsilesional lateral ventricle (d=-0.42). Worse chronic sensorimotor impairment specifically (measured by the Fugl-Meyer Assessment; n=256) was associated with smaller ipsilesional putamen (d=0.72) and larger lateral ventricle (d=-0.41) volumes, while several measures of activity limitations (n=116) showed no significant relationships. In the full cohort across all time (n=828), sensorimotor behaviour was associated with the volumes of the ipsilesional nucleus accumbens (d=0.23), putamen (d=0.33), thalamus (d=0.33) and lateral ventricle (d=0.23). We demonstrate significant relationships between post-stroke sensorimotor behaviour and reduced volumes of deep grey matter structures that were spared by stroke, which differ by time and class of sensorimotor measure. These findings provide additional insight into how different cortico-thalamo-striatal circuits support post-stroke sensorimotor outcomes.
AB - Up to two-thirds of stroke survivors experience persistent sensorimotor impairments. Recovery relies on the integrity of spared brain areas to compensate for damaged tissue. Deep grey matter structures play a critical role in the control and regulation of sensorimotor circuits. The goal of this work is to identify associations between volumes of spared subcortical nuclei and sensorimotor behaviour at different timepoints after stroke. We pooled high-resolution T1-weighted MRI brain scans and behavioural data in 828 individuals with unilateral stroke from 28 cohorts worldwide. Cross-sectional analyses using linear mixed-effects models related post-stroke sensorimotor behaviour to non-lesioned subcortical volumes (Bonferroni-corrected, P<0.004). We tested subacute (≤90 days) and chronic (≥180 days) stroke subgroups separately, with exploratory analyses in early stroke (≤21 days) and across all time. Sub-analyses in chronic stroke were also performed based on class of sensorimotor deficits (impairment, activity limitations) and side of lesioned hemisphere. Worse sensorimotor behaviour was associated with a smaller ipsilesional thalamic volume in both early (n=179; d=0.68) and subacute (n=274, d=0.46) stroke. In chronic stroke (n=404), worse sensorimotor behaviour was associated with smaller ipsilesional putamen (d=0.52) and nucleus accumbens (d=0.39) volumes, and a larger ipsilesional lateral ventricle (d=-0.42). Worse chronic sensorimotor impairment specifically (measured by the Fugl-Meyer Assessment; n=256) was associated with smaller ipsilesional putamen (d=0.72) and larger lateral ventricle (d=-0.41) volumes, while several measures of activity limitations (n=116) showed no significant relationships. In the full cohort across all time (n=828), sensorimotor behaviour was associated with the volumes of the ipsilesional nucleus accumbens (d=0.23), putamen (d=0.33), thalamus (d=0.33) and lateral ventricle (d=0.23). We demonstrate significant relationships between post-stroke sensorimotor behaviour and reduced volumes of deep grey matter structures that were spared by stroke, which differ by time and class of sensorimotor measure. These findings provide additional insight into how different cortico-thalamo-striatal circuits support post-stroke sensorimotor outcomes.
KW - MRI
KW - rehabilitation
KW - sensorimotor behaviour
KW - stroke
KW - subcortical volumes
UR - http://www.scopus.com/inward/record.url?scp=85132104458&partnerID=8YFLogxK
U2 - 10.1093/braincomms/fcab254
DO - 10.1093/braincomms/fcab254
M3 - Article
C2 - 34805997
AN - SCOPUS:85132104458
SN - 2632-1297
VL - 3
JO - Brain Communications
JF - Brain Communications
IS - 4
M1 - fcab254
ER -