Small RNAs recruit chromatin-modifying enzymes MMSET and Tip60 to reconfigure damaged DNA upon double-strand break and facilitate repair

Keyphrases

• DNA Damage 100%
• Reconfiguration 100%
• Chromatin-modifying Enzymes 100%
• Tip60 100%
• MMSET 100%
• Small RNA (sRNA) 100%
• Double-strand Break 100%
• DNA Damage Response 75%
• Lysine 50%
• Chromatin Remodeling 50%
• Double-strand Break Repair 50%
• Ago2 50%
• H2AX Phosphorylation 50%
• Chromatin 25%
• Molecular Mechanism 25%
• Breast Cancer 25%
• Histone H4 25%
• Histone H3 25%
• RAD51 25%
• RNA Molecules 25%
• RNA-based 25%
• New Layers 25%
• Histone Modification 25%
• Catalytic Activity 25%
• Chromatin Structure 25%
• DNA Double-strand Breaks 25%
• Methyltransferase 25%
• Demethylation 25%
• Acetyltransferase 25%
• Drosha 25%
• Trimethylation 25%
• Dicer 25%
• Local Level 25%
• WHSC1 25%
• KAT5 25%
• H4 Acetylation 25%
• H4K16ac 25%
• RNA-binding Activity 25%
• H4K20me2 25%
• Response Regulation 25%
• Small RNA Binding 25%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Chromatin 100%
• Small RNAs 100%
• DNA Damage Response 60%
• Chromatin Remodeling 40%
• Lysine 40%
• Histone H4 20%
• RNA 20%
• RNA Binding 20%
• BRCA1 20%
• N-Acetyltransferase 20%
• Methylation 20%
• Histone Modification 20%
• Acetylation 20%
• Methyltransferase 20%
• Drosha 20%
• Dicer 20%
• WHSC1 20%
• KAT5 20%
• Histone 20%
• Enzymatic Activity 20%
• Double-Strand DNA Break 20%
• Molecular Mechanism 20%