TY - JOUR
T1 - Small RNA-mediated epigenetic modifications in plants
AU - Simon, Stacey A.
AU - Meyers, Blake C.
N1 - Funding Information:
Work on plant small RNAs and epigenetics in the Meyers laboratory is supported by the NSF Plant Genome Research Program.
PY - 2011/4
Y1 - 2011/4
N2 - Epigenetic modifications in plants can be directed and mediated by small RNAs (sRNAs). This regulation is composed of a highly interactive network of sRNA-directed DNA methylation, histone, and chromatin modifications, all of which control transcription. Identification and functional characterization of components of the siRNA-directed DNA methylation pathway have provided insights into epigenetic pathways that form heterochromatin and into chromatin-based pathways for gene silencing, paramutation, genetic imprinting, and epigenetic reprogramming. Next-generation sequencing technologies have facilitated new discoveries and have helped create a basic blueprint of the plant epigenome. As the multiple layers of epigenetic regulation in plants are dissected, a more comprehensive understanding of the biological importance of epigenetic marks and states has been developed.
AB - Epigenetic modifications in plants can be directed and mediated by small RNAs (sRNAs). This regulation is composed of a highly interactive network of sRNA-directed DNA methylation, histone, and chromatin modifications, all of which control transcription. Identification and functional characterization of components of the siRNA-directed DNA methylation pathway have provided insights into epigenetic pathways that form heterochromatin and into chromatin-based pathways for gene silencing, paramutation, genetic imprinting, and epigenetic reprogramming. Next-generation sequencing technologies have facilitated new discoveries and have helped create a basic blueprint of the plant epigenome. As the multiple layers of epigenetic regulation in plants are dissected, a more comprehensive understanding of the biological importance of epigenetic marks and states has been developed.
UR - http://www.scopus.com/inward/record.url?scp=79955111192&partnerID=8YFLogxK
U2 - 10.1016/j.pbi.2010.11.007
DO - 10.1016/j.pbi.2010.11.007
M3 - Review article
C2 - 21159545
AN - SCOPUS:79955111192
SN - 1369-5266
VL - 14
SP - 148
EP - 155
JO - Current Opinion in Plant Biology
JF - Current Opinion in Plant Biology
IS - 2
ER -