Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Robert O. Hughes, Todd Bosanac, Xianrong Mao, Thomas M. Engber, Aaron DiAntonio, Jeffrey Milbrandt, Rajesh Devraj, Raul Krauss

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Axonal degeneration is prevalent in neurodegenerative disorders of the central and peripheral nervous systems. Hughes et al. developed potent small molecule inhibitors of SARM1, a central driver of axonal degeneration, that protect axons and allow recovery of already-injured axons that otherwise would degenerate. SARM1 inhibition may treat axonal degeneration.

Original languageEnglish
Article number108588
JournalCell Reports
Volume34
Issue number1
DOIs
StatePublished - Jan 5 2021

Keywords

  • ALS
  • CIPN
  • SARM1
  • Wallerian
  • WldS
  • axonal degeneration
  • axonopathy
  • multiple sclerosis
  • neurodegeneration
  • neuropathy

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