Abstract
Axonal degeneration is prevalent in neurodegenerative disorders of the central and peripheral nervous systems. Hughes et al. developed potent small molecule inhibitors of SARM1, a central driver of axonal degeneration, that protect axons and allow recovery of already-injured axons that otherwise would degenerate. SARM1 inhibition may treat axonal degeneration.
Original language | English |
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Article number | 108588 |
Journal | Cell Reports |
Volume | 34 |
Issue number | 1 |
DOIs | |
State | Published - Jan 5 2021 |
Keywords
- ALS
- CIPN
- SARM1
- Wallerian
- WldS
- axonal degeneration
- axonopathy
- multiple sclerosis
- neurodegeneration
- neuropathy