Axonal degeneration is prevalent in neurodegenerative disorders of the central and peripheral nervous systems. Hughes et al. developed potent small molecule inhibitors of SARM1, a central driver of axonal degeneration, that protect axons and allow recovery of already-injured axons that otherwise would degenerate. SARM1 inhibition may treat axonal degeneration.

Original languageEnglish
Article number108588
JournalCell Reports
Issue number1
StatePublished - Jan 5 2021


  • ALS
  • CIPN
  • SARM1
  • Wallerian
  • WldS
  • axonal degeneration
  • axonopathy
  • multiple sclerosis
  • neurodegeneration
  • neuropathy


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