Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Robert O. Hughes; Todd Bosanac; Xianrong Mao; Thomas M. Engber; Aaron DiAntonio; Jeffrey Milbrandt; Rajesh Devraj; Raul Krauss

doi:10.1016/j.celrep.2020.108588

Small Molecule SARM1 Inhibitors Recapitulate the SARM1^−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Robert O. Hughes, Todd Bosanac, Xianrong Mao, Thomas M. Engber, Aaron DiAntonio, Jeffrey Milbrandt, Rajesh Devraj, Raul Krauss

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Axonal degeneration is prevalent in neurodegenerative disorders of the central and peripheral nervous systems. Hughes et al. developed potent small molecule inhibitors of SARM1, a central driver of axonal degeneration, that protect axons and allow recovery of already-injured axons that otherwise would degenerate. SARM1 inhibition may treat axonal degeneration.

Original language	English
Article number	108588
Journal	Cell Reports
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.108588
State	Published - Jan 5 2021

Keywords

ALS
CIPN
SARM1
Wallerian
WldS
axonal degeneration
axonopathy
multiple sclerosis
neurodegeneration
neuropathy

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10.1016/j.celrep.2020.108588

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title = "Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate",

abstract = "Axonal degeneration is prevalent in neurodegenerative disorders of the central and peripheral nervous systems. Hughes et al. developed potent small molecule inhibitors of SARM1, a central driver of axonal degeneration, that protect axons and allow recovery of already-injured axons that otherwise would degenerate. SARM1 inhibition may treat axonal degeneration.",

keywords = "ALS, CIPN, SARM1, Wallerian, WldS, axonal degeneration, axonopathy, multiple sclerosis, neurodegeneration, neuropathy",

author = "Hughes, {Robert O.} and Todd Bosanac and Xianrong Mao and Engber, {Thomas M.} and Aaron DiAntonio and Jeffrey Milbrandt and Rajesh Devraj and Raul Krauss",

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AU - Bosanac, Todd

AU - Mao, Xianrong

AU - Engber, Thomas M.

AU - DiAntonio, Aaron

AU - Milbrandt, Jeffrey

AU - Devraj, Rajesh

AU - Krauss, Raul

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AB - Axonal degeneration is prevalent in neurodegenerative disorders of the central and peripheral nervous systems. Hughes et al. developed potent small molecule inhibitors of SARM1, a central driver of axonal degeneration, that protect axons and allow recovery of already-injured axons that otherwise would degenerate. SARM1 inhibition may treat axonal degeneration.

KW - ALS

KW - CIPN

KW - SARM1

KW - Wallerian

KW - WldS

KW - axonal degeneration

KW - axonopathy

KW - multiple sclerosis

KW - neurodegeneration

KW - neuropathy

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Small Molecule SARM1 Inhibitors Recapitulate the SARM1^−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Abstract

Keywords

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